Results 1 to 10 of about 66,622,600 (154)

Effectiveness of Tuberculous Recombinant Allergen Skin Tests for Detecting Tuberculosis in Children and Adolescents of Moscow in 2013 [PDF]

Pediatričeskaâ Farmakologiâ, 2015
Explanation. Mantoux test is used to detect the tuberculous infection; however, low specificity of this method results in a high rate of false positive responses due to cross-reactions of PPD (protein purified derivate) antigens contained in many ...
L. V. Slogotskaya, O. Y. Senchikhina, G. V. Nikitina, E. M. Bogorodskaya   +3 more
exaly   +4 more sources

Evaluation of the specificity of an intradermal test with recombinant tuberculosis allergen in Bacillus Calmette–Guérin-vaccinated healthy volunteers [PDF]

Frontiers in Medicine, 2023
IntroductionThe tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of Mycobacterium tuberculosis of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-
Irina A. Vasilyeva, Irina A. Vasilyeva, Valentina A. Aksenova, Valentina A. Aksenova, Alexey V. Kazakov, Alexey V. Kazakov, Alexey V. Kazakov, Yulia Y. Kiseleva, Andrey O. Maryandyshev, Elena N. Dolzhenko, Anna V. Abramchenko, Nadejda I. Klevno, Nadejda I. Klevno, Konstantin A. Glebov, Anna E. Panova, Larisa Y. Petrova, Elena G. Sheikis, Inna V. Seregina, Elena I. Nikishova, Natalia P. Doktorova, Anastasia G. Samoilova   +20 more
doaj   +2 more sources

Possible Use of Tuberculous Recombinant Allergen Test in the Differential Diagnosis of Diseases in the Upper Lung Lobes in Adults

Туберкулез и болезни лёгких, 2022
The objective of the study: to evaluate the possible use of the subcutaneous test with tuberculous recombinant allergen (TRA) in the differential diagnosis of pulmonary tuberculosis localized in the upper lobes.Subjects and Methods.
N. A. Stogova
doaj   +2 more sources

The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses. [PDF]

Curr Protoc, 2023
Abstract Epitopes recognized by T cells are a collection of short peptide fragments derived from specific antigens or proteins. Immunological research to study T cell responses is hindered by the extreme degree of heterogeneity of epitope targets, which are usually derived from multiple antigens; within a given antigen, hundreds of different T cell ...
da Silva Antunes R, Weiskopf D, Sidney J, Rubiro P, Peters B, Lindestam Arlehamn CS, Grifoni A, Sette A.   +7 more
europepmc   +2 more sources

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination. [PDF]

Immunol Rev, 2020
Abstract Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non‐infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination can at least in principle be proposed as a therapeutic strategy.
Schijns V, Fernández-Tejada A, Barjaktarović Ž, Bouzalas I, Brimnes J, Chernysh S, Gizurarson S, Gursel I, Jakopin Ž, Lawrenz M, Nativi C, Paul S, Pedersen GK, Rosano C, Ruiz-de-Angulo A, Slütter B, Thakur A, Christensen D, Lavelle EC.   +18 more
europepmc   +2 more sources

Comparative sensitivity of the test with tuberculosis recombinant allergen, containing ESAT6-CFP10 protein, and Mantoux test with 2 TU PPD-L in newly diagnosed tuberculosis children and adolescents in Moscow. [PDF]

PLoS ONE, 2018
BACKGROUND:A group of Russian scientists has developed Diaskintest, which comprises Mycobacterium tuberculosis-specific recombinant proteins CFP10-ESAT6, for skin testing (0.2 μg/0.1 ml).
Liudmila Slogotskaya, Elena Bogorodskaya, Diana Ivanova, Tatiana Sevostyanova   +3 more
doaj   +2 more sources

Design and development of a multi‐epitope vaccine for the prevention of latent tuberculosis infection

Medicine Advances, Volume 1, Issue 4, Page 361-382, December 2023., 2023
Abstract Background Latent tuberculosis infection (LTBI) often progresses to active tuberculosis, necessitating the development of novel vaccine to prevent LTBI. In this study, we aimed to design a Mycobacterium tuberculosis (M. tuberculosis) vaccine that could elicit a potent immune response to prevent LTBI.
Fan Jiang, Lingling Wang, Jie Wang, Peng Cheng, Jing Shen, Wenping Gong   +5 more
wiley   +1 more source

Latent tuberculosis infection among university students

Туберкулез и болезни лёгких, 2020
Objective: to study the prevalence of latent tuberculosis infection (LTBI) among university students, to evaluate the effectiveness of preventive treatment in students with LTBI.Subjects and methods. In 2016-2019, the three-stage study was conducted that
O. D. Baranova, V. A. Аksenova, N. I. Klevno, V. S. Odinets   +3 more
doaj   +1 more source

Diaskintest for the diagnosis of bovine tuberculosis

Туберкулез и болезни лёгких, 2021
The objective of the study: to compare the diagnostic value of intracutaneous tests with tuberculin and diaskintest for detection of tuberculosis in cattle.Subjects and methods.
A. Kh. Naymanov, A. M. Gulyukin, N. G. Tolstenko, E. P. Vangeli, V. M. Kalmykov   +4 more
doaj   +1 more source

The Use of Rifapentine for Preventive Chemotherapy in Children from Risk Groups of Developing Tuberculosis

Туберкулез и болезни лёгких, 2022
The objective: to compare efficacy of preventive treatment of children with latent tuberculosis infection using various regimens of anti-tuberculosis drugs and assess the risk of adverse events to these drugs.Subjects and Methods.
O. D. Baronova, V. A. Aksenova, E. F. Luginova, E. N. Dolzhenko   +3 more
doaj   +1 more source