Results 111 to 120 of about 114,872 (265)

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Chronic high-fat diet decreases global histone H4 acetylation and increases HDAC8 expression in mouse testes. [PDF]

Biochem Biophys Rep
Aizawa S, Ohno H, Yamamuro Y.
europepmc   +1 more source

Viscosity of concentrated mRNA solutions: Implications for downstream processing

Biotechnology Progress, EarlyView.
Abstract Messenger RNA (mRNA) therapeutics can be used to protect against infectious disease and for the treatment of cancers and genetic disorders. In order to obtain the desired therapeutic dosage, it is necessary to concentrate the mRNA to levels where the viscosity of the mRNA solutions can become significant.
Amin Javidanbardan, Fatemeh Najafi, Ziqiao Wang, Andrew L. Zydney   +3 more
wiley   +1 more source

Optimizing Care for Undescended Testicles in Children and Adolescents-Diagnosis, Management, and Outcomes: A Narrative Review of Current Evidence. [PDF]

Children (Basel)
Bašković M, Buzuk J, Dujić B, Jurić D, Jurković K, Pehar K, Vuković S, Ježek D, Habek D, Milas I.   +9 more
europepmc   +1 more source

Personalized Gamified Learning in a Course on the Urogenital System Anatomy: Differential Effects Across Learning Preference Profiles

Clinical Anatomy, EarlyView.
ABSTRACT Personalized learning approaches adapted to individual metacognitive characteristics have demonstrated promise in Anatomy education. However, whether such benefits are uniform across learner profiles or vary systematically remains an open question with implications for individualized instructional approaches.
Mónica Stambuk‐Castellano, Alejandro Ortega‐Arranz, Anna Carrera, Enrique Verdú, R. Shane Tubbs, Joe Iwanaga, Francisco Reina   +6 more
wiley   +1 more source

Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis. [PDF]

Elife
Zhao C, Chen Y, Liu L, Liu X, Xiao H, Wang F, Huang Q, Dai X, Tao W, Wang D, Wei J.   +10 more
europepmc   +1 more source

Modified F‐tests for assessing tree radial growth under linear‐circular regression models with correlated errors: A comprehensive toolbox rooted in G. E. P. Box's theorems

Canadian Journal of Statistics, EarlyView.
Abstract Annual tree growth is a complex biological process. Modelling radial growth in the trunk by linear‐circular regression with one mode and correlated errors has allowed the definition and assessment of a preferred direction for 1 and 2 years. Here, modified F$$ F $$‐tests are presented for 3 years, 1 mode/year; 1 year, 2 modes for possible main ...
Pierre Dutilleul, Tomoaki Imoto, Kunio Shimizu   +2 more
wiley   +1 more source