Results 91 to 100 of about 268,034 (314)

Non-tumorous testes.

open access: yes, 2013
(A) Box plot analysis of the size of non-tumorous testes in WKY/Ztm and WKY-Dnd1ter/Ztm with wild type (+/+), heterozygous (ter/+) and homozygous (ter/ter) genotype at 3, 6 and 9 weeks of age. ter/ter testes are degenerated and significantly smaller than
Regina Eisenblätter (321897)   +7 more
core   +1 more source

Spectrum of Congenital Anomalies in Myhre Syndrome—Insights Into Effects Brought by Altered TGF‐β Signaling via Gain‐of‐Function Variants in SMAD4

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is a rare genetic disorder characterized by progressive multisystem involvement. Gain‐of‐function missense heterozygous variants affecting the Ile500 residue and Arg496 residue of the SMAD4 gene are implicated in this condition.
Kawmadi Gunawardena   +13 more
wiley   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang   +14 more
wiley   +1 more source

Monitoração da geração distribuída em sistemas de distribuição via testes geométricos de colinearidade [PDF]

open access: yes, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Este trabalho apresenta uma metodologia para monitoração em tempo real da geração distribuída em sistemas de ...
Souza, Aline Terezinha de
core  

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu   +6 more
wiley   +1 more source

Toxicidade de hidrocarbonetos monoaromáticos do petróleo sobre metamysidopsis elongata atlantica (crustacea: mysidacea) [PDF]

open access: yes, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro tecnológico. Programa de Pós-Graduação em Engenharia AmbientalO petróleo é uma mistura complexa de inúmeros compostos orgânicos, com predominância de hidrocarbonetos, e sua ...
Vieira, Francyne Carolina dos Santos
core  

Immunohistochemical staining of testes.

open access: yes, 2013
(A) anti c-kit staining and (B) anti DDX4/MVH staining of paraffin sections from homozygous ter/ter and wild type testes of WKY-Dnd1ter/Ztm rats at 10 days, 3 weeks and 6 weeks of age (black arrows: clusters of surviving c-kit positive germ cell ...
Regina Eisenblätter (321897)   +7 more
core   +1 more source

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat   +5 more
wiley   +1 more source

kallisto testes

open access: yes, 2016
Kallisto generated counts of expression for testes reads mapped to the annotated reproductive ...
MacManes, Matthew D.   +3 more
core   +1 more source

Photochemisch erzeugte Oxetane als Schlüssel zur endergonen Cyclopropansynthese

open access: yesAngewandte Chemie, EarlyView.
Eine neuartige Oxetan‐zu‐Cyclopropan‐Umlagerung eröffnet einen atomökonomischen Zugang zu dicht funktionalisierten Cyclopropanen aus Furanen und photochemisch aktivierten Aldehyden. Die erhaltenen Strukturen erschließen komplexe bioaktive Motive und fungieren als vielseitige Plattform für die asymmetrische Cyclopropansynthese.
Tim Köglmeier   +2 more
wiley   +1 more source

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