Results 61 to 70 of about 54,598 (390)

Noncoder : a web interface for exon array-based detection of long non-coding RNAs [PDF]

open access: yes, 2012
Due to recent technical developments, a high number of long non-coding RNAs (lncRNAs) have been discovered in mammals. Although it has been shown that lncRNAs are regulated differently among tissues and disease statuses, functions of these transcripts ...
Braun, Thomas   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Prognostic significance of ingibin B with infertile patients (review of references)

open access: yesАндрология и генитальная хирургия, 2015
Infertility is a polyetiological disease and requires modern universal markers, studying of which could allow determination of the appropriate tactics of treatment of patients with impaired fertility, evaluation of prognosis, and prospects of treatment ...
Z. A. Kadyrov   +2 more
doaj   +3 more sources

Role of spermatozoa in pH stability of caudal epididymis environment [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2019
50 ram testicles where been collected directly after slaughtering, preserved in cool box (8-10°C) and transferred to the andrological lab at the Veterinary Medicine Collage / University of Baghdad.
Saleh Mahdi   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman   +5 more
wiley   +1 more source

On the hypertrophy of the interstitial cells in the testicle of the guinea-pig under different experimental conditions

open access: yes, 1922
Quantitative problems are, no doubt, of the greatest theoretical and practical interest in the study of the internal secretion of the sexual glands. We are explaining different physiological and clinical situations by changes in the quantity of internal ...
A. Lipschütz   +3 more
semanticscholar   +1 more source

The Cowl - v.59 - n.13 - Nov 10, 1994 [PDF]

open access: yes, 1994
The Cowl - student newspaper of Providence College. Volume 59, Number 13 - November 10, 1994.

core   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan   +3 more
wiley   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche   +8 more
wiley   +1 more source

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