Abstract Background Animal cancer registry data are important for monitoring animal health, for prevention and research in veterinary medicine, and for comparative oncology. Since people and animals share the same environment and are exposed to many common risk factors, cancer patterns in animals may have a sentinel function for human health.
Claudio Trentin +10 more
wiley +1 more source
Extracranial, Extragonadal Germ Cell Tumors: A Multicenter Australian Case Series
Extragonadal germ cell tumors (EGCTs) are rare, with limited prospective data to guide treatment or inform prognosis. Incidence and treatment patterns of EGCT in Australia reflect international data and practices. Compared to testicular primaries, the prognosis of EGCT is poor, especially for primary mediastinal non‐seminoma.
Kar Ven Cavan Chow +19 more
wiley +1 more source
Reassessing pre-existing comorbidity patterns in testicular cancer: controversies and future directions. [PDF]
Chen Y, Liu Y, Liu C.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Testicular cancer: a bibliometric review of the Middle East and North African region. [PDF]
Nasrallah OG +8 more
europepmc +1 more source
The Promise of Mindfulness-Based Interventions: A Stress-Reduction Strategy for Testicular Cancer Survivors' Health-Related Quality of Life. [PDF]
Rovito MJ +4 more
europepmc +1 more source
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
Impact of Population Pharmacogenomics on Cisplatin-Induced Neurotoxicities in Testicular Cancer Survivors. [PDF]
Nakshatri S +11 more
europepmc +1 more source
ABSTRACT Objective There is inconsistent data on cancer risk in people with intellectual disability. Our primary objective was to compare the incidence of cancer in people with and without intellectual disability. Methods and Analysis A cohort study using linked population‐based administrative and cancer registry data in New South Wales, Australia 2001–
Julian Trofimovs +4 more
wiley +1 more source
Reply: Reassessing pre-existing comorbidity patterns in testicular cancer: controversies and future directions. [PDF]
Ornstrup MJ +3 more
europepmc +1 more source

