Results 181 to 190 of about 70,701 (334)

Burned-out testicular cancer - case report

open access: yesQuality in Sport
Introduction and Purpose Germ cell tumors of the testis are the most common malignant tumors in young men aged 15-40, although their incidence in the male population is about 1-1.5%. 90-98% of all testicular tumors originate from germ cells. There has
Mateusz Szarek   +3 more
doaj   +1 more source

Deubiquitinase TRIM44 Promotes Autophagy‐Mediated Chemoresistance in Diffuse Large B Cell Lymphoma

open access: yesHematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin lymphoma. Tripartite motif containing 44 (TRIM44) belonging to the TRIM family, is involved in tumor development and is highly expressed in a variety of tumors. However, the role of TRIM44 in DLBCL remains undefined. Gain and loss‐of‐function studies were performed
Yan Wang   +7 more
wiley   +1 more source

Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence [PDF]

open access: bronze, 2004
Alfredo Velasco   +6 more
openalex   +1 more source

Histopathological Features of the Testes of a Patient With Congenital Lipoid Adrenal Hyperplasia

open access: yesIJU Case Reports, Volume 8, Issue 4, Page 386-389, July 2025.
ABSTRACT Introduction Congenital lipoid adrenal hyperplasia (CLAH) is a type of congenital adrenal hyperplasia characterized by reduced steroid production. Patients with this endocrine disorder as well as chromosome 46,XY have testes and female external genitalia. Because these individuals are usually raised as female, the testes are removed.
Takuya Sakata   +9 more
wiley   +1 more source

Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer

open access: yesCell Reports, 2017
Summary: Testicular germ cell tumors (TGCTs) are among the most responsive solid cancers to conventional chemotherapy. To elucidate the underlying mechanisms, we developed a mouse TGCT model featuring germ cell-specific Kras activation and Pten ...
Timothy M. Pierpont   +15 more
doaj  

Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors [PDF]

open access: yes, 2018
The epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis, therapy and prognosis of various tumor types. The aim of this study was to investigate EGFR expression in a large series of testicular germ cell tumors (TGCTs).
Hechelhammer, Lukas   +4 more
core  

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar   +10 more
wiley   +1 more source

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