Med Research, EarlyView.ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin +8 more
wiley +1 more source
MRI in the Histologic Characterization of Testicular Neoplasms
American Journal of Roentgenology, 2007 The purpose of our study was to investigate the potential role of MRI in the preoperative characterization of the histologic type of testicular tumors and, more specifically, to differentiate seminomatous from nonseminomatous testicular neoplasms.Twenty-one patients with histologically proven germ cell testicular tumors underwent MRI of the scrotum on ...
Tsili, A. C. +6 more
openaire +4 more sources
Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. [PDF]
, 2018 Adenomatoid tumors are the most common neoplasm of the epididymis, and histologically similar adenomatoid tumors also commonly arise in the uterus and fallopian tube.
Bastian, Boris C +13 more
core +1 more source
Assessment and classification of sex cord-stromal tumours of the testis: recommendations from the testicular sex cord-stromal tumour (TESST) group, an Expert Panel of the Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP). [PDF]
HistopathologyFH immunohistochemistry is recommended in clinically malignant Leydig cell tumours and in primary Leydig cell tumours with aggressive histopathologic features. Aims Testicular sex cord‐stromal tumours (TSCSTs) are relatively rare, accounting for ~5% of all testicular neoplasms.
Acosta AM +21 more
europepmc +2 more sources
Med Research, EarlyView.ABSTRACT With the global aging trend intensifying, cancer presents a significant health challenge for the elderly. This study aims to assess the prevalence, mortality, and disability‐adjusted life years (DALY) burden of cancer among individuals aged 60–94 worldwide from 1990 to 2021.
Xiaohan Zhu +4 more
wiley +1 more source
Canine testicular tumours: a retrospective investigation in Abruzzo and Molise, Italy [PDF]
Veterinaria Italiana, 2012 Canine testicular tumours frequently occur and share relevant features with their human counterparts, thus being a putative model in comparative oncology. The authors present data on canine testicular tumours submitted to the Istituto G.
Anna Rita D’Angelo +3 more
doaj
Classic Testicular Seminoma in Men Aged 50 Years or Over: A Case Report and Review of the Literature
Case Reports in Urology, 2019 Testicular cancer is the most frequent solid tumor detected in young adult men. Germ cell tumors (GCTs), particularly seminomas, are the most common type of testicular neoplasms seen in that age population.
Rawad Abou Zahr +7 more
doaj +1 more source
Case Illustrating Recent Radical Operation for Testicular Neoplasm [PDF]
, 1933 C. Hope Carlton
openalex +1 more source
Thyroxine-binding globulin: investigation of microheterogeneity [PDF]
, 1981 Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland +4 more
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source