Results 181 to 190 of about 47,128 (346)

Assessment of new prognostic risk models for recurrence in patients with clinical stage I seminoma

open access: yesBJU International, EarlyView.
Objectives To evaluate two new prognostic risk models aimed at improving clinical decision‐making in patients with clinical stage (cS) I seminomatous testicular germ cell tumours (GCTs), 5%–30% of whom experience recurrence during surveillance after orchiectomy and may benefit from adjuvant therapy.
Angelina Strauch   +4 more
wiley   +1 more source

Extremely rare synchronous primary neoplasms in testicular cancer patients

open access: gold, 2019
Bela Mriňáková   +3 more
openalex   +2 more sources

Nuclear destabilisation – a possible genesis of cancer?

open access: yesBiological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott   +4 more
wiley   +1 more source

Integrative Transcriptomic Analysis Decodes the Interplay Between Aging, Senescence, and Cancer

open access: yesCancer Science, EarlyView.
By integrating analysis of genomics, epigenomics, bulk‐ and single‐cell transcriptomics, we revealed a directionally opposite transcriptional profile between cellular senescence and tumorigenesis at the sigle‐cell level, which may be affected by epigenomic regulations.
Jiale Cai   +14 more
wiley   +1 more source

Downregulation of Chromosome 19 miRNA Cluster and the Tumor‐Suppressive Role of miR‐517a‐3p in Choriocarcinoma

open access: yesCancer Science, EarlyView.
Chromosome 19 microRNA cluster was downregulated in choriocarcinoma compared with complete hydatidiform mole. miR‐517a‐3p reduced the proliferation, migration, and invasion abilities of choriocarcinoma cell lines. Downregulation of SRSF1, targeted by miR‐517a‐3p, suppressed the malignant potential of choriocarcinoma cell lines. ABSTRACT Choriocarcinoma
Yuki Nishiko   +14 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

open access: yesCell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu   +4 more
wiley   +1 more source

Testicular Neoplasms and Other Abnormalities in Common Carp Cyprinus carpio from the Lower Colorado River, United States [PDF]

open access: gold
Vicki S. Blazer   +5 more
openalex   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

open access: yesEuropean Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

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