Results 61 to 70 of about 22,224 (299)

Testicular degeneration and infertility following arbovirus infection [PDF]

, 2018
Arboviruses can cause a variety of clinical signs including febrile illness, arthritis, encephalitis and hemorrhagic fever. The recent Zika epidemic highlighted the possibility that arboviruses may also negatively affect the male reproductive tract.
Dattena, Maria, Ligios, Ciriaco, Maestrale, Caterina, Manunta, Daniela, Meloni, Giorgio, Melzi, Eleonora, Oggiano, Annalisa, Palmarini, Massimo, Pintus, Davide, Puggioni, Giantonella, Rocchigiani, Angela Maria, Savini, Giovanni   +11 more
core   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Testicular volume is a noninvasive predictor of sperm retrieval failure in idiopathic nonobstructive azoospermia

Asian Journal of Andrology
We investigated the prognostic importance of noninvasive factors in predicting sperm retrieval failure in idiopathic nonobstructive azoospermia (iNOA). We studied 193 patients with nonobstructive azoospermia who underwent microsurgical testicular sperm ...
Hong Xiao, Song-Xi Tang, Rui-Jie Yao, Yi-Lang Ding, Peng Yang, Qiang Chen, Hai-Lin Huang, Xi Chen, Hui-Liang Zhou   +8 more
doaj   +1 more source

Disorders of sex development (DSD): an overview of recent scientific advances [PDF]

, 2014
Developments in biotechnology have radically altered clinical and research themes in the small field of disorders of sex development, as in other rare medical conditions. In the age of genetics, an increasing number of DSDs have been identified. Aided by
Conway, GS
core  

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

The role of surgical sperm retrieval techniques in patients with azoospermia in assisted reproductive technology programs (literature review)

Андрология и генитальная хирургия, 2018
This literature review is dedicated to surgical sperm retrieval techniques, such as percutaneous and microsurgical epididymal sperm aspiration, testicular sperm aspiration, testicular sperm extraction (standard, microdissection, multifocal).
S. I. Gamidov, A. Yu. Popova, N. G. Gasanov, R. I. Ovchinnikov, N. P. Naumov, T. V. Shatylko   +5 more
doaj   +1 more source

Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism [PDF]

, 2016
Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development.
A Giwercman, A Kamarianos, AA Pacey, B Bush, BC Dunphy, D Balabanic, DJ Handelsman, E Carlsen, EJ Gubbels, F Chauvigne, G Dolf, G England, G Toft, G Toft, GC England, GCW England, HM Koch, HVU Brandsch, IC Oskam, IN Pathirana, J Axelsson, J Suominen, J Vitku, J-C Lu, JD Meeker, K Bay, K Choi, KA Boisen, L Robertson, LH Looijenga, M Rolland, MS Bloom, N Jorgensen, N Pant, N Pant, NE Skakkebaek, P Pocar, P Pocar, R Hauser, R Hauser, R Rozati, RL Wahl, RM Sharpe, RP Amann, S Ali, S Aquila, S Aquila, SC Smith, SH Swan, SH Swan, SM Rhind, SM Rhind, SW Seager, T Serrano, V Grieco, V Grieco, V Grieco, VR Kay, WG Foster, WV Holt, YX Wang   +60 more
core   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

ICSI outcome after microdissection testicular sperm extraction, testicular sperm aspiration and ejaculated sperm

Reproductive Biology
We conducted a case-controlled single-center cohort study to evaluate the intracytoplasmic sperm injection (ICSI) outcome in severe male infertility with different methods of sperm obtention. The data was compiled from a tertiary university hospital.
Rauni Klami, Candido Tomás, Harri Mankonen, Antti Perheentupa   +3 more
openaire   +2 more sources

Testicular sperm extraction with intracytoplasmic sperm injection for nonobstructive azoospermia

Urology, 1997
To provide fertility for men with nonobstructive azoospermia.A retrospective review of treatment results at a university infertility center was undertaken. Sixteen couples entered an attempted in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) cycle for treatment of nonobstructive azoospermia.
P N, Schlegel, G D, Palermo, M, Goldstein, S, Menendez, N, Zaninovic, L L, Veeck, Z, Rosenwaks   +6 more
openaire   +2 more sources