Results 161 to 170 of about 25,819,872 (363)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

USE OF INTERNATIONAL DOCUMENTS FOR QUALITY CONTROL OF EDUCATIONAL ASSESSMENT IN UKRAINE

open access: yesІнформаційні технології і засоби навчання, 2010
The article is devoted to quality assurance of educational assessment – international approaches and prospects for use of international recommendations at the current stage of development of educational assessment in Ukraine.
Iryna Ye. Bulakh, Maryna R. Mrouga
doaj  

Validity and Reliability of an On‐Bike Sensor System for the Determination of Aerodynamic Drag in Cycling

open access: yesEuropean Journal of Sport Science
Cycling performance is strongly influenced by aerodynamics, with most resistive drag forces being attributed to the rider. The Body Rocket device (BR) is an on‐bike sensor system that uses the same load cell technology as a wind tunnel, directly ...
James G. Hopker   +3 more
doaj   +1 more source

Random effects structure for confirmatory hypothesis testing: Keep it maximal.

open access: yesJournal of Memory and Language, 2013
D. Barr   +3 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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