Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park+6 more
wiley +1 more source
Cascade testing effectively identifies undiagnosed sickle cell disease in The Gambia: a quality improvement project. [PDF]
Deans-Louis E, Allen A, Allen SJ.
europepmc +1 more source
Characterizations of Complete Classes of Tests of Some Multiparametric Hypotheses, with Applications to Likelihood Ratio Tests [PDF]
Allan Birnbaum
openalex +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren+4 more
wiley +1 more source
Assessing Gaps in Integrated HIV and STI Testing Among New York State-Funded Providers by Pre-exposure Prophylaxis Status: Implications for Status-Neutral Programming. [PDF]
Tesoriero JM+5 more
europepmc +1 more source
Asymptotic Behavior of Some Rank Tests for Analysis of Variance [PDF]
Fred C. Andrews
openalex +1 more source
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh+6 more
wiley +1 more source
Uptake, utility and resource requirements of a genetic counselling telephone helpline within the BRCA-DIRECT digital pathway for mainstreamed BRCA testing in patients with breast cancer. [PDF]
Torr B+23 more
europepmc +1 more source
FURTHER REFINEMENT OF A TECHNIQUE FOR TESTING CONTACT INSECTICIDES
W. S. Mcleod
openalex +2 more sources