Results 61 to 70 of about 6,038,565 (279)

The Problems and Design of a Neck Dummy

open access: yesBiomimetics
This paper addresses the biomechanical requirements and design of a neck dummy for assessing neck injury risks. The need for an accurate biomechanical representation of the human neck in crash tests is highlighted, emphasizing the importance of ...
Christopher René Torres San Miguel   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

The reliability and discriminant validity of physical, technical, and perceptual-physiological measures during a game-specific basketball activity simulation protocol

open access: yesFrontiers in Psychology
Activity simulation protocols offer useful applications in research and practice; however, the specificity of such protocols to basketball game-play is currently lacking.
Davide Ferioli   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Putting formal specifications under the magnifying glass: Model-based testing for validation [PDF]

open access: yes, 2009
A software development process is effectively an abstract form of model transformation, starting from an end-user model of requirements, through to a system model for which code can be automatically generated.
Mark Utting   +12 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

İngilizceyi Yabancı Dil Olarak Öğrenen Öğrencilerin ve Öğretmenlerin Portfolyo Hakkındaki Algıları: Bir Polis Hırsız Kovalamacası

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2011
Alternatif değerlendirmenin önemi, İngiliz dili eğitimine hem teori, hem de pratik anlamda en son katkısağlayan etmenlerden biri olarak kabul görmesine ve portfolyo bazlıdeğerlendirme biçiminin dil eğitimi veren çoğu okullarda bulunmasına rağmen, Türkiye’
Adem Soruç
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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