Results 81 to 90 of about 3,424,389 (246)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Manufacturing of Agricultural Machinery Metal Parts Using Additive Sheet Lamination Technology

Механика машин, механизмов и материалов
Possibilities and prospects are considered for application of additive sheet lamination technology for direct manufacturing of agricultural machinery metal parts on the example of manufacturing of plow steel beam.
Nikolay K. Tolochko, Pavel V. Auramenka, Vyacheslav B. Kravtsov, Andrey P. Levshukov, Kirill Yu. Astreyko   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ABOUT THE NECESSARY AND SUFFICIENT CONDITION FOR THE EXISTENCE VALIDATION OF FUNCTIONAL TEST OF MINIMUM POSSIBLE LENGTH FOR A ONE-DIMENSIONAL ITERATIVE PATTERNS

Nauka ta progres transportu, 2007
The problem of confidence testing applying to the regular iterative circuits is considered. Total number of such circuits from one class is estimated.
O. I. Tymoshkin
doaj  

Method of testing the software of spacecraft electronic equipment based on fault injection in the algorithms of orientation and stabilization

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение
The purpose of the work is to develop and describe a new method of testing spacecraft electronic equipment. The article substantiates the relevance of developing new methods and means of testing on-board electronic equipment of spacecraft based on the ...
D. A. Nedorezov, A. I. Postnikov, A. V. Murigin, A. V. Shnaider   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On terminology awareness of the first-year physical education students

Вестник Северо-Кавказского федерального университета
Introduction. Successful development and constructive use of the conceptual and terminological apparatus are the most important conditions for ensuring high-quality educational and practical activities in the field of physical culture.Goal.
V. P. Lukyanenko, V. I. Goncharov, N. V. Lukyanenko   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source