Results 71 to 80 of about 3,601,648 (237)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Enhanced Particle Swarm Optimization for Automated Compatibility Testing in Cloud-based Distributed Systems

Journal of Cross-Disciplinary Sustainability Innovations
Ensuring software compatibility in cloud-based distributed systems presents significant challenges due to the heterogeneous nature of cloud environments and the complexity of distributed architectures.
Dai Li, Weishuo Lan
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Coverage and determinants of HIV testing and counseling services among mothers attending antenatal care in sub-Saharan African countries: a multilevel analysis

BMC Public Health
Background HIV/AIDS is one of the top global public health threats that causes significant cases, deaths, and socioeconomic impact. Even though both HIV testing and counseling are identified as essential HIV interventions during pregnancy, large ...
Temam Beshir Raru, Bedasa Taye Merga, Alemayehu Deressa, Abdi Birhanu, Galana Mamo Ayana, Belay Negash, Mulugeta Gamachu, Addisu Alemu, Fila Ahmed Hassen, Ahmed Mohammed, Dawit Firdisa, Lemma Demissie Regassa   +11 more
doaj   +1 more source

HIV testing coverage among female sex workers, Brazil, 2016

Revista Brasileira de Epidemiologia
Introduction: Knowing the factors associated with periodic HIV testing among female sex workers (FSW) is essential to expand testing coverage and to broaden programs of treatment as prevention.
Ana Maria de Brito, Célia Landmann Szwarcwald, Giseli Nogueira Damacena, Inês Costa Dourado   +3 more
doaj   +1 more source

Evaluating the Impact of Test-and-Treat on the HIV Epidemic among MSM in China Using a Mathematical Model.

PLoS ONE, 2015
BackgroundVarious studies have modeled the impact of test-and-treat policies on the HIV epidemics worldwide. However, few modeling studies have taken into account China's context.
Sitong Luo, Litao Han, Hongyan Lu, Zhi Dou, Qian Tao, Kaveh Khoshnood, Zunyou Wu, Jie Xu   +7 more
doaj   +1 more source

Programmatic implications of implementing the relational algebraic capacitated location (RACL) algorithm outcomes on the allocation of laboratory sites, test volumes, platform distribution and space requirements

African Journal of Laboratory Medicine, 2017
Introduction: CD4 testing in South Africa is based on an integrated tiered service delivery model that matches testing demand with capacity. The National Health Laboratory Service has predominantly implemented laboratory-based CD4 testing. Coverage gaps,
Naseem Cassim, Honora Smith, Lindi M. Coetzee, Deborah K. Glencross   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A subset of precise UML for Model-based Testing [PDF]

, 2007
This paper presents an original model-based testing approach that takes a UML behavioural view of the system under test and automatically generates test cases and executable test scripts according to model coverage criteria.
Legeard, B, Vacelet, N., Vacelet, Nicolas, Bouquet, Fabien, B. Legeard, F. Peureux, Bouquet, F, Grandpierre, Christophe, Grandpierre, C., Bouquet, Fabrice, F. Bouquet, C. Grandpierre, Legeard, Bruno, Grandpierre, C, Peureux, Fabien, Peureux, F, Utting, Mark, M. Utting, N. Vacelet, Vacelet, N   +19 more
core   +1 more source