Results 51 to 60 of about 3,601,648 (237)
Who Pays? Coverage Challenges for Cardiovascular Genetic Testing in U.S. Patients
Frontiers in Cardiovascular Medicine, 2016 Inherited cardiovascular conditions are common, and comprehensive care of affected families often involves genetic testing. When the clinical presentations of these conditions overlap, genetic testing may clarify diagnoses, etiologies, and treatments in ...
Katherine Grace Spoonamore +1 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Testing, Testing, Read All About It: Canadian Press Coverage of the PISA Results
Canadian Journal of Education, 2006 This article is a critical discourse analysis of coverage in the National Post and the Globe and Mail concerning the Organisation for Economic Co‐operation and Development’s 2000 Programme for International Student Assessment (PISA).
Michelle Stack
doaj +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Impact of delays on effectiveness of contact tracing strategies for COVID-19: a modelling study
The Lancet Public Health, 2020 Summary: Background: In countries with declining numbers of confirmed cases of COVID-19, lockdown measures are gradually being lifted. However, even if most physical distancing measures are continued, other public health measures will be needed to ...
Mirjam E Kretzschmar, ProfPhD +5 more
doaj +1 more source
Moving forward with combinatorial interaction testing [PDF]
, 2013 Combinatorial interaction testing (CIT) is an efficient and effective method of detecting failures that are caused by the interactions of various system input parameters. In this paper, we discuss CIT, point out some of the difficulties of applying it in
Demiröz, Gülşen +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Full Coverage Testing Method for Automated Driving System in Logical Scenario Parameters Space
SensorsScenario-based testing is a mainstream approach for evaluating the safety of automated driving systems (ADS). However, logical scenarios are defined through parameter spaces, and performance differences among systems under test make it difficult to ...
Haitao Min +5 more
doaj +1 more source