Results 51 to 60 of about 378,895 (264)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Changes in self‐reported HIV testing during South Africa's 2010/2011 national testing campaign: gains and shortfalls

Journal of the International AIDS Society, 2016
Objectives HIV counselling and testing is critical to HIV prevention and treatment efforts. Mass campaigns may be an effective strategy to increase HIV testing in countries with generalized HIV epidemics.
Brendan Maughan‐Brown, Neil Lloyd, Jacob Bor, Atheendar S Venkataramani   +3 more
doaj   +1 more source

HPV Serology Testing Confirms High HPV Immunisation Coverage in England. [PDF]

PLoS ONE, 2016
BACKGROUND:Reported human papillomavirus (HPV) vaccination coverage in England is high, particularly in girls offered routine immunisation at age 12 years.
David Mesher, Elaine Stanford, Joanne White, Jamie Findlow, Rosalind Warrington, Sukamal Das, Richard Pebody, Ray Borrow, Kate Soldan   +8 more
doaj   +1 more source

Test Coverage Criteria for Agent Interaction Testing [PDF]

, 2011
By the very definition of complex systems, complex behaviour emerges from the interactions between the individual parts. This emergent behaviour may be difficult or impossible to predict by analysing the parts. As a result, systematic and thorough testing of the interactions of complex systems, including multi-agent systems, is an important part of the
Tim Miller 0001, Lin Padgham, John Thangarajah   +2 more
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CSEFuzz: Fuzz Testing Based on Symbolic Execution

IEEE Access, 2020
Fuzz testing has been successful in finding defects of various software packages. These defects include file parsing, image processing, Internet browsers, and network protocols.
Zhangwei Xie, Zhanqi Cui, Jiaming Zhang, Xiulei Liu, Liwei Zheng   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Full Coverage Testing Method for Automated Driving System in Logical Scenario Parameters Space

Sensors
Scenario-based testing is a mainstream approach for evaluating the safety of automated driving systems (ADS). However, logical scenarios are defined through parameter spaces, and performance differences among systems under test make it difficult to ...
Haitao Min, Zhiqiang Zhang, Tianxin Fan, Peixing Zhang, Cheng Zhang, Ge Qu   +5 more
doaj   +1 more source

Research on Optimization of Test Case Generation Based on Neuron Coverage Index [PDF]

Jisuanji kexue
DNNs have been widely applied in many fields,and testing them is particularly important due to their complexity and uncertainty.Traditional testing methods rely too much on a single indicator and cannot fully reveal the complete behavioral patterns of ...
XIAO Ziqin, SHI Yaqing, QU Yubin
doaj   +1 more source