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Testis Development. [PDF]

Endocrine Reviews, 2018
Production of sperm and androgens is the main function of the testis. This depends on normal development of both testicular somatic cells and germ cells.
Juho-Antti Mäkelä, J. Koskenniemi, H. Virtanen, J. Toppari   +3 more
semanticscholar   +3 more sources

Profiling of testis-specific long noncoding RNAs in mice

BMC Genomics, 2018
Background Spermatogenesis, which is the complex and highly regulated process of producing haploid spermatozoa, involves testis-specific transcripts. Recent studies have discovered that long noncoding RNAs (lncRNAs) are novel regulatory molecules that ...
Seong Hyeon Hong, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Seonhee Lee, Chunghee Cho   +6 more
doaj   +2 more sources

DMRT1 prevents female reprogramming in the postnatal mammalian testis

Nature, 2011
Sex in mammals is determined in the fetal gonad by the presence or absence of the Y chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicular Sertoli cells or ovarian granulosa cells. This pivotal decision in a
Vivian J Bardwell, David Zarkower
exaly   +2 more sources

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration

eLife, 2016
The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation.
Francisco J Barrionuevo, Alicia Hurtado, Gwang-Jin Kim, Francisca M Real, Mohammed Bakkali, Janel L Kopp, Maike Sander, Gerd Scherer, Miguel Burgos, Rafael Jiménez   +9 more
doaj   +2 more sources

Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering

Frontiers in Cell and Developmental Biology, 2022
Gene editing in male germline stem (GS) cells is a potent tool to study spermatogenesis and to create transgenic mice. Various engineered nucleases already demonstrated the ability to modify the genome of GS cells. However, current systems are limited by
Mariella Obermeier, Jim Vadolas, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert   +5 more
doaj   +1 more source

Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

Basic and Clinical Andrology, 2021
Résumé Contexte Le testicule représente un lieu où le précurseur de la vitamine D est converti en sa forme active. Il a été suggéré que la perte d’un testicule pouvait induire une réduction des taux sériques de vitamine D.
Klaus-Peter Dieckmann, Osama Andura, Uwe Pichlmeier, Klaus Martin Otte, Hendrik Isbarn, Christian Wülfing   +5 more
doaj   +1 more source

Long-Term Maintenance and Meiotic Entry of Early Germ Cells in Murine Testicular Organoids Functionalized by 3D Printed Scaffolds and Air-Medium Interface Cultivation

Frontiers in Physiology, 2021
Short-term germ cell survival and central tissue degeneration limit organoid cultures. Here, testicular organoids (TOs) were generated from two different mouse strains in 3D printed one-layer scaffolds (1LS) at the air-medium interface displaying tubule ...
Guillaume Richer, Robin M. Hobbs, Katherine L. Loveland, Katherine L. Loveland, Ellen Goossens, Yoni Baert   +5 more
doaj   +1 more source

Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia

Life, 2023
About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied.
Margo Willems, Céline Devriendt, Catharina Olsen, Ben Caljon, Toon Janssen, Inge Gies, Veerle Vloeberghs, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +9 more
doaj   +1 more source

ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection

medRxiv, 2020
In December 2019 and January 2020, novel coronavirus (2019-nCoV) - infected pneumonia (NCIP) occurred in Wuhan, and has already posed a serious threat to public health.
Caibin Fan, Kai Li, Yanhong Ding, W. Lu, Jianqing Wang   +4 more
semanticscholar   +1 more source

Transcriptomic differences between fibrotic and non-fibrotic testicular tissue reveal possible key players in Klinefelter syndrome-related testicular fibrosis

Scientific Reports, 2022
Klinefelter syndrome (KS; 47,XXY) affects 1–2 in 1000 males. Most men with KS suffer from an early germ cell loss and testicular fibrosis from puberty onwards. Mechanisms responsible for these processes remain unknown. Previous genomics studies on testis
Margo Willems, Catharina Olsen, Ben Caljon, Veerle Vloeberghs, Jean De Schepper, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +7 more
doaj   +1 more source