Results 1 to 10 of about 256,197 (272)

Profiling of testis-specific long noncoding RNAs in mice

BMC Genomics, 2018
Background Spermatogenesis, which is the complex and highly regulated process of producing haploid spermatozoa, involves testis-specific transcripts. Recent studies have discovered that long noncoding RNAs (lncRNAs) are novel regulatory molecules that ...
Seong Hyeon Hong, Jun Tae Kwon, Jihye Kim, Juri Jeong, Jaehwan Kim, Seonhee Lee, Chunghee Cho   +6 more
doaj   +2 more sources

Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering

Frontiers in Cell and Developmental Biology, 2022
Gene editing in male germline stem (GS) cells is a potent tool to study spermatogenesis and to create transgenic mice. Various engineered nucleases already demonstrated the ability to modify the genome of GS cells. However, current systems are limited by
Mariella Obermeier, Jim Vadolas, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert   +5 more
doaj   +1 more source

Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

Basic and Clinical Andrology, 2021
Résumé Contexte Le testicule représente un lieu où le précurseur de la vitamine D est converti en sa forme active. Il a été suggéré que la perte d’un testicule pouvait induire une réduction des taux sériques de vitamine D.
Klaus-Peter Dieckmann, Osama Andura, Uwe Pichlmeier, Klaus Martin Otte, Hendrik Isbarn, Christian Wülfing   +5 more
doaj   +1 more source

Long-Term Maintenance and Meiotic Entry of Early Germ Cells in Murine Testicular Organoids Functionalized by 3D Printed Scaffolds and Air-Medium Interface Cultivation

Frontiers in Physiology, 2021
Short-term germ cell survival and central tissue degeneration limit organoid cultures. Here, testicular organoids (TOs) were generated from two different mouse strains in 3D printed one-layer scaffolds (1LS) at the air-medium interface displaying tubule ...
Guillaume Richer, Robin M. Hobbs, Katherine L. Loveland, Katherine L. Loveland, Ellen Goossens, Yoni Baert   +5 more
doaj   +1 more source

Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia

Life, 2023
About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied.
Margo Willems, Céline Devriendt, Catharina Olsen, Ben Caljon, Toon Janssen, Inge Gies, Veerle Vloeberghs, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +9 more
doaj   +1 more source

ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCoV Infection

medRxiv, 2020
In December 2019 and January 2020, novel coronavirus (2019-nCoV) - infected pneumonia (NCIP) occurred in Wuhan, and has already posed a serious threat to public health.
Caibin Fan, Kai Li, Yanhong Ding, W. Lu, Jianqing Wang   +4 more
semanticscholar   +1 more source

Transcriptomic differences between fibrotic and non-fibrotic testicular tissue reveal possible key players in Klinefelter syndrome-related testicular fibrosis

Scientific Reports, 2022
Klinefelter syndrome (KS; 47,XXY) affects 1–2 in 1000 males. Most men with KS suffer from an early germ cell loss and testicular fibrosis from puberty onwards. Mechanisms responsible for these processes remain unknown. Previous genomics studies on testis
Margo Willems, Catharina Olsen, Ben Caljon, Veerle Vloeberghs, Jean De Schepper, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +7 more
doaj   +1 more source

Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle

International Journal of Molecular Sciences, 2020
Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant non-collagenous protein in bone, was demonstrated to inhibit bone formation and function as a hormone, which regulates glucose metabolism in the pancreas ...
T. Komori
semanticscholar   +1 more source

Toxicological Effects of Cadmium on Mammalian Testis

Frontiers in Genetics, 2020
Cadmium is a heavy metal, and people are exposed to it through contaminated foods and smoking. In humans and other mammals, cadmium causes damage to male testis.
Q. Zhu, Xiaoheng Li, R. Ge
semanticscholar   +1 more source

Immune Cell Subtypes and Their Function in the Testis

Frontiers in Immunology, 2020
Immunoregulation in the testis is characterized by a balance between immuno-suppression (or immune privilege) and the ability to react to infections and inflammation.
S. Bhushan, M. Theas, V. Guazzone, P. Jacobo, Ming Wang, M. Fijak, A. Meinhardt, L. Lustig   +7 more
semanticscholar   +1 more source