Results 1 to 10 of about 359,825 (361)

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration [PDF]

eLife, 2016
The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation.
Francisco J Barrionuevo, Alicia Hurtado, Gwang-Jin Kim, Francisca M Real, Mohammed Bakkali, Janel L Kopp, Maike Sander, Gerd Scherer, Miguel Burgos, Rafael Jiménez   +9 more
doaj   +4 more sources

R-spondin 1/Dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis [PDF]

, 2015
Testicular vasculogenesis is one of the key processes regulating male gonad morphogenesis. The knowledge of the molecular cues underlining this phenomenon is one of today's most challenging issues and could represent a major contribution toward a better ...
Caruso, Maria, Catizone, Angela, Ciccarone, Fabio, Corano Scheri, Katia, Dobrowolny, Gabriella, Ferranti, Francesca, Grammatico, Paola, Ricci, Giulia   +7 more
core   +18 more sources

Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering

Frontiers in Cell and Developmental Biology, 2022
Gene editing in male germline stem (GS) cells is a potent tool to study spermatogenesis and to create transgenic mice. Various engineered nucleases already demonstrated the ability to modify the genome of GS cells. However, current systems are limited by
Mariella Obermeier, Jim Vadolas, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert   +5 more
doaj   +1 more source

Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

Basic and Clinical Andrology, 2021
Résumé Contexte Le testicule représente un lieu où le précurseur de la vitamine D est converti en sa forme active. Il a été suggéré que la perte d’un testicule pouvait induire une réduction des taux sériques de vitamine D.
Klaus-Peter Dieckmann, Osama Andura, Uwe Pichlmeier, Klaus Martin Otte, Hendrik Isbarn, Christian Wülfing   +5 more
doaj   +1 more source

Long-Term Maintenance and Meiotic Entry of Early Germ Cells in Murine Testicular Organoids Functionalized by 3D Printed Scaffolds and Air-Medium Interface Cultivation

Frontiers in Physiology, 2021
Short-term germ cell survival and central tissue degeneration limit organoid cultures. Here, testicular organoids (TOs) were generated from two different mouse strains in 3D printed one-layer scaffolds (1LS) at the air-medium interface displaying tubule ...
Guillaume Richer, Robin M. Hobbs, Katherine L. Loveland, Katherine L. Loveland, Ellen Goossens, Yoni Baert   +5 more
doaj   +1 more source

Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia

Life, 2023
About half of testicular sperm extraction (TESE) procedures in men with non-obstructive azoospermia (NOA), including men with Klinefelter syndrome (KS), are unsuccessful. To avoid unnecessary invasive surgery, biomarkers for spermatozoa were studied.
Margo Willems, Céline Devriendt, Catharina Olsen, Ben Caljon, Toon Janssen, Inge Gies, Veerle Vloeberghs, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +9 more
doaj   +1 more source

Transcriptomic differences between fibrotic and non-fibrotic testicular tissue reveal possible key players in Klinefelter syndrome-related testicular fibrosis

Scientific Reports, 2022
Klinefelter syndrome (KS; 47,XXY) affects 1–2 in 1000 males. Most men with KS suffer from an early germ cell loss and testicular fibrosis from puberty onwards. Mechanisms responsible for these processes remain unknown. Previous genomics studies on testis
Margo Willems, Catharina Olsen, Ben Caljon, Veerle Vloeberghs, Jean De Schepper, Herman Tournaye, Dorien Van Saen, Ellen Goossens   +7 more
doaj   +1 more source

Torsion of the appendix testis in undescended testes as a rare cause of groin swelling

Journal of Pediatric Surgery Case Reports, 2021
A 10 year-old boy presented to the emergency department with torsion of an Appendix Testis in an undescended testis. The diagnosis was suspected clinically and confirmed by ultrasound imaging. Intra-operatively, the testis was well perfused.
Daniel Pasquale Cinelli, Fadi Atwan, Anne G. Carroll, Salvatore Cascio   +3 more
doaj   +1 more source

Does co-transplantation of mesenchymal and spermatogonial stem cells improve reproductive efficiency and safety in mice?

Stem Cell Research & Therapy, 2019
Background Spermatogonial stem cell transplantation (SSCT) is a promising therapy in restoring the fertility of childhood cancer survivors. However, the low efficiency of SSCT is a significant concern.
Prashant Kadam, Elissavet Ntemou, Jaime Onofre, Dorien Van Saen, Ellen Goossens   +4 more
doaj   +1 more source

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Geissler, Claudia, Jochum, Marianne, Naegler, Dorit K., Nerlich, Andreas, Neth, Peter, Profanter, Birgit, Sommerhoff, Christian P.   +6 more
core   +1 more source