Results 101 to 110 of about 256,296 (370)

Building the mammalian testis: origins, differentiation, and assembly of the component cell populations

Genes & Development, 2013
Testis development in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male reproduction and endocrine regulation.
T. Svingen, P. Koopman
semanticscholar   +1 more source

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

The effect of low doses of cadmium and zinc chloride on the Blood-Testis Barrier of Sprague Dawley rats [PDF]

arXiv, 2012
Background: Cadmium chloride is an environmental toxic that affects the male reproductive system. This study was directed 1) to evaluate whether long-term oral exposures to low doses of Cd in rats causes morphological changes, 2) the immunohistochemical TJ and AJ protein expression; and 3) to evidence that zinc exposure can modify Cd effects.
arxiv  

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Autogenous self‐healing of concrete: Experimental design and test methodsA review

Engineering Reports, Volume 5, Issue 1, January 2023., 2023
Concrete exhibits an intrinsic ability to heal cracks, defined as “autogenous self‐healing.” However, despite code restrictions, autogenous self‐healing of concrete shows limited effectiveness in practice. This indicates the need for further research to provide engineers with reliable design rules.
Daniel Lahmann, Carola Edvardsen, Sylvia Kessler   +2 more
wiley   +1 more source

The Significance of the Contralateral Testis Size Measurement with Ultrasonography in Predicting Monorchism in Boys with Nonpalpable Testicles

Journal of Urological Surgery, 2017
Objective: The aim of this study was to determine the significance of contralateral testis size in predicting monorchism in pediatric patients with unilateral undescended testis.
Çağrı Akın Şekerci, Yılören Tanıdır, Tarık Emre Şener, Ruslan Asadov, Ahmet Şahan, Tufan Tarcan, Ferruh Şimsek, Cem Akbal   +7 more
doaj   +1 more source

The onset of cluster formation around Herbig Ae/Be stars [PDF]

arXiv, 1998
The large body of near infrared observations presented in Testi et al. (1997; 1998) are analysed with the aim of characterizing the young stellar clusters surrounding Herbig Ae/Be stars. The results confirm the tendency of early Be stars to be surrounded by dense clusters of lower mass "companions", while Ae stars are never found to be associated with ...
arxiv  

PAX7 expression defines germline stem cells in the adult testis.

Journal of Clinical Investigation, 2014
Spermatogenesis is a complex, multistep process that maintains male fertility and is sustained by rare germline stem cells. Spermatogenic progression begins with spermatogonia, populations of which express distinct markers.
G. Aloisio, Y. Nakada, H. Saatcioglu, C. G. Peña, Michael D. Baker, E. Tarnawa, Jishnu Mukherjee, Hema Manjunath, Abhijit Bugde, Anita Sengupta, J. Amatruda, I. Cuevas, F. Hamra, D. Castrillon   +13 more
semanticscholar   +1 more source

The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy

Advanced Science, EarlyView.
This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley   +1 more source

Limited sex differences in plastic responses suggest evolutionary conservatism of thermal reaction norms: A meta‐analysis in insects

Evolution Letters, Volume 6, Issue 6, Page 394-411, December 2022., 2022
Abstract Temperature has a profound effect on the growth and development of ectothermic animals. However, the extent to which ecologically driven selection pressures can adjust thermal plastic responses in growth schedules is not well understood. Comparing temperature‐induced plastic responses between sexes provides a promising but underexploited ...
Tiit Teder, Kristiina Taits, Ants Kaasik, Toomas Tammaru   +3 more
wiley   +1 more source