Results 141 to 150 of about 185,233 (313)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Normal spermatogenesis and fertility in <i>Spmip8</i> deficiency male mice. [PDF]

Biochem Biophys Rep
Zhang Z, Hu M, Yan D, Zhao Y, Tao W, Chen S, Qi M, Luo L, Jiang X, Xu B, Bai S.   +10 more
europepmc   +1 more source

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an ex vivo human testis model. [PDF]

Hum Reprod
Franklin L, Kuassivi ON, Satie AP, Abiven H, Mathieu R, Miaadi N, Plotton I, Le Tortorec A, Dejucq-Rainsford N.   +8 more
europepmc   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Right-Sided Triorchidism: A Rare Case of Supernumerary Testis in a Young Adult Male. [PDF]

Cureus
Ewida T, Abuismaeil M, Quddus M, Kolevski I, Khan Z.   +4 more
europepmc   +1 more source

Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics

С. Б. Петров, A. V. Arnautov, Karina Nikulina, С. А. Рева, A. D. Tsaregorodtseva, Yu. A. Tikhonova   +5 more
openalex   +2 more sources

Evolving Features of RASopathies Among Pregnancies With Abnormal Fetal Fluid Collections

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective We aimed to characterize the fetal features across gestation and describe genotype‐phenotype correlations for pregnancies with fetal RASopathies that were more severely affected as they presented with at least one abnormal fluid collection.
Natalie B. Gulrajani, John Boscardin, Billie R. Lianoglou, Katie Tick, Carmen M. A. Santoli, Kristen A. Miller, Angie C. Jelin, Lorraine Dugoff, Rose Giardine, Cori Feist, Rachel Pilliod, Stephanie Dukhovny, Kelly Gilmore, Neeta L. Vora, Aisling Murphy, Peter N. Robinson, Mary E. Norton, Teresa N. Sparks   +17 more
wiley   +1 more source

Data from ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib

, 2023
Wenlong Li, Rolf W. Sparidans, Margarida L.F. Martins, Mujtaba El-Lari, Maria C. Lebre, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel   +7 more
openalex   +2 more sources

Extra-pancreatic solid pseudopapillary neoplasm: a case report of primary testis origin and review of the literature. [PDF]

Front Oncol
Lu Q, Yang L, Li S.
europepmc   +1 more source