Results 141 to 150 of about 165,252 (194)

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Phenotype and gene signature of testicular tumors in 129.MOLF‐Chr19 mice resemble human teratomas

Andrology, EarlyView.
Abstract Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal‐type teratomas arise independently of the GCNIS.
Fabian A. Gayer, Lucas Klaus, Sybille D. Reichardt, Alexander Fichtner, Holger M. Reichardt   +4 more
wiley   +1 more source

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility

Andrology, EarlyView.
Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer, Ann‐Kristin Dicke, Frank Tüttelmann   +2 more
wiley   +1 more source

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants

Andrology, EarlyView.
Abstract Background Small RNAs interacting with PIWI (piRNAs) play a crucial role in regulating transposable elements and translation during spermatogenesis and are essential in male germ cell development. Disruptions in the piRNA pathway typically lead to severe spermatogenic defects and thus male infertility. The HENMT1 gene is a key player in piRNAs
Zeina Wehbe, Anne‐Laure Barbotin, Angèle Boursier, Caroline Cazin, Jean‐Pascal Hograindleur, Marie Bidart, Emeline Fontaine, Pauline Plouvier, Florence Puch, Véronique Satre, Christophe Arnoult, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas Thierry‑Mieg, Pierre F. Ray, Zine‑Eddine Kherraf, Charles Coutton, Guillaume Martinez   +17 more
wiley   +1 more source

Ascorbic acid 2‐glucoside improves survival, quality, and fertility of frozen‐thawed C57Bl/6J and C57Bl/6N mouse spermatozoa

Andrology, EarlyView.
Abstract Background Ascorbic acid 2‐glucoside (AA2G) is a stabilized form of ascorbic acid and a potent antioxidant. Ascorbic acid is present in the testes and epididymis and helps maintain the physiological integrity of reproductive organs. Its properties have been utilized to protect spermatozoa of different species from oxidative stress.
Marcello Raspa, Renata Paoletti, Ferdinando Scavizzi   +2 more
wiley   +1 more source

THE PERINEAL TESTIS

Annals of Surgery, 1938
openaire   +4 more sources

Rapid detection of mouse spermatogenic defects by testicular cellular composition analysis via enhanced deep learning model

Andrology, EarlyView.
Abstract Background Histological analysis of the testicular sections is paramount in infertility research but tedious and often requires months of training and practice. Objectives Establish an expeditious histopathological analysis of mutant mice testicular sections stained with commonly available hematoxylin and eosin (H&E) via enhanced deep learning
Nianfei Ao, Min Zang, Yue Lu, Yiping Jiao, Haoda Lu, Chengfei Cai, Xiangxue Wang, Xin Li, Minge Xie, Tingting Zhao, Jun Xu, Eugene Yujun Xu   +11 more
wiley   +1 more source

Machine learning‐based classification of varicocoele grading: A promising approach for diagnosis and treatment optimization

Andrology, EarlyView.
Abstract Background Varicocoele is a correctable cause of male infertility. Although physical examination is still being used in diagnosis and grading, it gives conflicting results when compared to ultrasonography‐based varicocoele grading. Objectives We aimed to develop a multi‐class machine learning model for the grading of varicocoeles based on ...
Mehmet Vehbi Kayra, Ali Şahin, Serdar Toksöz, Mehmet Serindere, Emre Altıntaş, Halil Özer, Murat Gül   +6 more
wiley   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

Dexamethasone is a regulator of clock genes in testicular peritubular cells

Andrology, EarlyView.
Abstract Background We recently found that peritubular cells of the human testis are a dominant site of expression of the glucocorticoid receptor (GR; encoded by NR3C1). Activation of GR by dexamethasone (Dex) strongly influences the phenotype of cultured human testicular peritubular cells (HTPCs), causing massive changes of their proteome and ...
Harald Welter, Nicole Kreitmair, Michaela Schneider, Julia Schneider, Stoyan Petkov, Youli Stepanov, Frank‐Michael Köhn, Ulrich Pickl, Matthias Trottmann, Thomas Fröhlich, Rüdiger Behr, Artur Mayerhofer   +11 more
wiley   +1 more source