Results 151 to 160 of about 165,252 (194)

EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice

Andrology, EarlyView.
Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang, Longsheng Zhang, Li Yu, Xinli Zhou, Xu Chen, Yuchuan Zhou, Ningling Wang, Hui Zhu   +7 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice

Andrology, EarlyView.
Abstract Background Inhibition of sperm maturation in the epididymis is a promising post‐testicular strategy for short‐acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice.
Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida‐Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M. Matzuk, Masahito Ikawa   +9 more
wiley   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Update on andrological effects of SARS‐CoV‐2 infection and COVID‐19: An overview review

Andrology, EarlyView.
Abstract Background Evidence indicates a wide range of andrological alterations in patients with the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS‐CoV‐2) infection and Coronavirus Disease 2019 (COVID‐19). Aim To provide an update on the andrological effects of SARS‐CoV‐2 infection and COVID‐19.
Giuseppe Lisco, Anna De Tullio, Maima Matin, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola, Giuseppina Piazzolla, Vincenzo Triggiani   +7 more
wiley   +1 more source

A non‐hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation

Andrology, EarlyView.
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi, Aditi Khamamkar, Kwaku Kyei‐Baffour, Michel Weïwer, Srinivasan Vijayaraghavan, Souvik Dey   +5 more
wiley   +1 more source

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VANISHED TESTIS: BE AWARE OF AN ABDOMINAL TESTIS

Journal of Urology, 2000
Vanished testes are thought to result from a vascular accident, such as torsion of the developing gonad. We report a case in which a nubbin was found in the scrotum with torsion of the ipsilateral unattached abdominal testis. Without laparoscopy the intra-abdominal testis would have remained undiscovered, exposing the patient to increased risk of ...
J.M. Nijman, K.P. Wolffenbuttel, D.J. Kok, J.C. Den Hollander   +3 more
openaire   +4 more sources

Torsion of the Testis [PDF]

Scandinavian Journal of Urology and Nephrology, 1972
22 cases operated on for testicular torsion at Gentofte Hospital Surgical Department H are reported.The material is devided into two maingroups, i.e. 11 cases in whom the testes seemed to be saved by the operation and 11 cases in whom hemicastration had to be done.
openaire   +3 more sources

PDGF and the testis

Trends in Endocrinology & Metabolism, 2002
Testicular development is controlled by a complex hierarchy of gene regulatory proteins, growth factors, cell adhesion molecules, signaling molecules and hormones that interact, often acting within short time windows, via reciprocal control relationships.
Stefania Mariani, BASCIANI, Sabrina, Mario Arizzi, Giovanni Spera, GNESSI, Lucio   +4 more
openaire   +3 more sources