Results 211 to 220 of about 502,065 (385)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment

Journal of the American Medical Association (JAMA), 2017
S. Resnick, A. Matsumoto, A. Stephens-Shields, S. Ellenberg, T. Gill, S. Shumaker, Debbie Pleasants, E. Barrett-Connor, S. Bhasin, J. Cauley, D. Cella, J. Crandall, G. Cunningham, K. Ensrud, J. Farrar, C. Lewis, M. Molitch, M. Pahor, R. Swerdloff, Denise Cifelli, S. Anton, S. Basaria, S. Diem, Christina Wang, Xiaoling Hou, P. Snyder   +25 more
semanticscholar   +1 more source

Association Between Dietary Intake of Omega-3 Fatty Acids and Serum Testosterone in Adult Males: Results From NHANES 2011-2016 and 2021-2023. [PDF]

Food Sci Nutr
Su L, Zhang SZ, Cheng HY, Zhang Q, Zhou ZY, Wu J, Jiao YZ.   +6 more
europepmc   +1 more source

The biosynthesis and metabolism of oestrogens in the rat. 1. Conversion of [4-14C]testosterone into [14C]oestradiol-17β by the rat ovary [PDF]

, 1963
S. R. Stitch, R. E. OAKEY, SS Eccles
openalex   +1 more source

An Open‐Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT To establish bioequivalence (BE) of a generic test formulation with respect to a reference listed drug, it is necessary to demonstrate a comparable rate and extent to which active ingredients reach the site of action. To decrease unnecessary human testing and simulate scenarios involving specific populations or challenges with recruitment or ...
Abdullah Hamadeh, Moriah Pellowe, Pierre Chelle, Cindy Hoi Ting Yeung, Julian Otalvaro, Walter Yamada, Jay Bartroff, Alona Kryshchenko, André Dallmann, Juri Solodenko, Jörg Lippert, Eleftheria Tsakalozou, Michael Neely, Andrea Edginton   +13 more
wiley   +1 more source

Testosterone Pellets in Women: Revisiting Safety and Clinical Outcomes. [PDF]

Cureus
Pinto da Costa Viana D, Jacobsen L, Gabriel LH, Lobo de Souza Correia E, da Maia Fernandes D, Nagel ML, Comin A.   +6 more
europepmc   +1 more source

The biosynthesis and metabolism of oestrogens in the rat. 2. The conversion of [4-14C]testosterone into [14C]oestradiol-17β by the ovary after whole-body irradiation [PDF]

, 1963
S. R. Stitch, R. E. OAKEY, SS Eccles
openalex   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism. [PDF]

Cardiovasc Diabetol
Bonnet F, Vaduva P, Halimi JM, Dosda A, Ducluzeau PH, Koppe L, Fauchier L.   +6 more
europepmc   +1 more source

SYNTHESIS AND METABOLIC STUDIES OF 17-METHYL-C14-TESTOSTERONE

, 1954
Paul M. Hyde, William H. Elliott, Edward A. Doisy, Edward A. Doisy   +3 more
openalex   +1 more source