Results 91 to 100 of about 1,377 (227)

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue   +3 more
wiley   +1 more source

Development of new aromatase inhibitors analogues of letrozole: perspectives for treatment of male infertility [PDF]

open access: yes, 2016
Nowadays, infertility is one of the major health issues. Human fertility depends on several psychological, physical and biochemical factors, with a successful spermatogenesis being the fundamental basis for male fertility.
Coelho, Anaísa Nascimento
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Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong   +5 more
wiley   +1 more source

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Women with polycystic ovary syndrome (PCOS) exhibit a substantially increased risk of miscarriage, yet the underlying mechanisms remain inadequately understood. This study aimed to investigate whether specific gut microbial dysbiosis and metabolic disturbance are associated with and may potentially contribute to endometrial ...
Mengyu Jing   +9 more
wiley   +1 more source

Studies relating hepatic cytosolic [|H]-estradiol binding proteins to hormonal and drug modulation of hepatic microsomal aryl hydrocarbon hydroxylase in the rat

open access: yes, 1983
Pituitary hormones are known to alter sex steroid receptor levels in the liver, and possibly the actions of the steroids as well. Recently, two classes of estrogen binding proteins have been characterized in male rat hepatic cytosol: a high affinity, low
Finlayson, Malcolm John Paul
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Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

open access: yesIntegrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Gonadal Development–Related Genes and a Male‐Specific Genetic Marker Identified in the Endangered Sichuan Taimen (Hucho bleekeri)

open access: yesIntegrative Zoology, EarlyView.
Integrated transcriptomic and proteomic analyses were used to validate gonadal development–related genes and to identify a sex‐specific molecular marker in Hucho bleekeri. ABSTRACT Sex determination and differentiation represent fundamental topics in reproductive biology. Sichuan taimen (Hucho bleekeri), a first‐class national protected fish species in
Qinyao Wei   +5 more
wiley   +1 more source

Development, validation and routine application of the in vitro REA and DR-CALUX reporter gene bioassays for the screening of estrogenic compounds and dioxins in food and feed

open access: yes, 2006
A dedicated cell-line was developed by the Department of Toxicology of Wageningen University in a joined project with the University of California in Davis and the RIKILT-WUR - Institute of Food Safety in Wageningen.
Bovee, T.F.H.
core   +1 more source

Saving Water to Survive: Alternative Water Loss Strategies Could Explain Color Polymorphism Maintenance in a Lacertid Lizard

open access: yesIntegrative Zoology, EarlyView.
We demonstrate that red male Podarcis muralis exhibit higher evaporative water loss compared to other morphs, indicating a physiological strategy that prioritizes hydroregulation over fine thermoregulation. This suggests red morphs are adapted to cooler, wetter niches, while white and yellow morphs possess superior water conservation mechanisms to ...
Roberto Sacchi   +10 more
wiley   +1 more source

Int J Hyg Environ Health [PDF]

open access: yes
Dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ether (PBDE) flame retardants, and polychlorinated biphenyls (PCBs) are believed to be endocrine-disrupting chemicals (EDCs) in humans and animals. The purpose of this study is to examine the

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