Results 151 to 160 of about 1,377 (227)

Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates. [PDF]

Cell Biol Toxicol
Strand D, Nylander E, Höglund A, Lundgren B, Martin JW, Karlsson O.   +5 more
europepmc   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Closer to the Heart: Cardiac Muscle Aerobic Capacity Correlates With Intraspecific Variation in Sprint Performance Rather Than Androgen Levels in the Neotropical Lizard Tropidurus catalanensis. [PDF]

J Exp Zool A Ecol Integr Physiol
Lima WS, Giacometti D, Schaeffer PJ, de Carvalho JE.   +3 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

The potential health risks of exposure to environmental chemicals - Global implications for future generations. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci
Kishi R, Ikeda A, Ketema RM.
europepmc   +1 more source

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, EarlyView.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction. [PDF]

Front Behav Neurosci
Jocsak G, Kiss DS, Alymbaeva D, Diebald A, Zsarnovszky A, Heinzlmann A, Bartha T.   +6 more
europepmc   +1 more source

Anabolic-androgenic steroid use disorder: case for recognition as a substance use disorder with specific diagnostic criteria. [PDF]

Br J Psychiatry
Scarth M, Havnes IA, Bjørnebekk A.
europepmc   +1 more source

Health and Well‐Being Beyond Residential Care: Implications for Extended Care Service Responses for Young People

Child &Family Social Work, EarlyView.
ABSTRACT Care leavers often encounter considerable health and well‐being challenges, underscoring the need for continued support into early adulthood. This small‐scale mixed‐methods study explored the health, well‐being and extended care experiences of participants in the South Australian Next Steps pilot program for residential care leavers, assessed ...
Sally‐Ann Keipert, Helen McLaren, Samuel Carpenter, Michelle Jones   +3 more
wiley   +1 more source