Results 141 to 150 of about 1,324 (186)

The role of the aryl hydrocarbon receptor in ovarian development, function, xenobiotic metabolism, and disease†. [PDF]

Biol Reprod
Dean AE, Flaws JA.
europepmc   +1 more source

Health and Well‐Being Beyond Residential Care: Implications for Extended Care Service Responses for Young People

Child &Family Social Work, EarlyView.
ABSTRACT Care leavers often encounter considerable health and well‐being challenges, underscoring the need for continued support into early adulthood. This small‐scale mixed‐methods study explored the health, well‐being and extended care experiences of participants in the South Australian Next Steps pilot program for residential care leavers, assessed ...
Sally‐Ann Keipert, Helen McLaren, Samuel Carpenter, Michelle Jones   +3 more
wiley   +1 more source

Harm reduction techniques among cisgender gay, bisexual, and queer men using anabolic androgenic steroids: a qualitative study. [PDF]

Harm Reduct J
Kutscher E, Arshed A, Greene RE, Kladney M.   +3 more
europepmc   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, EarlyView.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory. [PDF]

Environ Health
van Larebeke N, Cox B, Remy S, Voorspoels S, Den Hond E, Colles A, Leermakers M, Schoeters G, Verheyen V.   +8 more
europepmc   +1 more source

Absence of Interaction Between 5α‐Reductase Inhibitors and Glucocorticoids on Incidence of Myocardial Infarction in People With Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims People with Type 2 diabetes experience higher cardiometabolic risk, and both synthetic glucocorticoids and use of 5α‐reductase inhibitors have been individually linked to increased risk of myocardial infarction. We tested whether the increase in risk is exacerbated by co‐prescription of both drugs.
Haolan Tu, Chengsheng Ju, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Scottish Diabetes Research Network Epidemiology Group, Peter Hanlon, Robert Lindsay, David McAllister, John Petrie, Naveed Sattar, Brian Kennon, Sam Philip, Scott Cunningham, Huan Wang, William Berthon, Helen Colhoun, Paul McKeigue, Sarah Wild, Ewan R. Pearson, Li Wei, Ruth Andrew   +20 more
wiley   +1 more source

The world's first anabolic-androgenic steroid testing trial: A two-phase pilot combining chemical analysis, results dissemination and community feedback. [PDF]

Addiction
Piatkowski T, Coomber R, Francis C, Kill E, Davey G, Cresswell S, White A, Harding M, Blakey K, Reeve S, Walters B, Puljevic C, Ferris J, Barratt M.   +13 more
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source

Seasonal Differences in Community-level Mobbing Responses of Passerines Toward a Diurnal Owl in Taiwan. [PDF]

Zool Stud
Chen TC, Tsai JS.
europepmc   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source