Results 121 to 130 of about 1,377 (227)

Parental Educational Attainment at Birth and Biomarkers of Male Fecundity: A Study From the Danish National Birth Cohort

open access: yesAndrology, EarlyView.
ABSTRACT Background Low parental education is associated with poorer offspring health, but its influence on male fecundity remains unclear. Objective To study the association between parental educational attainment at birth and biomarkers of male fecundity in young men and to explore whether this association is mediated by maternal smoking in pregnancy
Anne Hjorth Thomsen   +6 more
wiley   +1 more source

The effect of prenatal low level exposure of PCB 118 (2 3' 4 4' 5-pentachlorobiphenyl)on developmental and reproductive outcoms in male rat offspring

open access: yes, 2011
[[abstract]]多氯聯苯 118(2,3',4,4',5-pentachlorobiphenyl, PCB 118)屬單鄰位PCB同類異構物,脂溶性高且易藉由食物鏈而累積在脂肪與人類乳汁中,具有反映PCB總毒性當量之特性。研究指出暴露PCB 118,可能與甲狀腺、肝臟危害與致癌性有關,但目前對PCB 118影響生殖功能研究不多。本研究目的藉動物模式探討暴露低濃度PCB 118對雄性第一子代(F1)與第二子代(F2)大鼠生長發育與生殖危害的影響 ...
Wu Yi-Lun, 吳翊綸
core  

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

open access: yesAndrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda   +7 more
wiley   +1 more source

Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome

open access: yesAndrology, EarlyView.
ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Aksh Tailor   +6 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

open access: yesAndrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

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