Results 91 to 100 of about 1,739,242 (280)

Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR/PGC1α/TFAM Pathway

Frontiers in Genetics, 2019
Mammalian mitochondrial biogenesis is a complex process involving mitochondrial proliferation and differentiation. Mitochondrial DNA transcription factor A (TFAM), which encodes a major component of a protein-mitochondrial DNA (mtDNA) complex, is ...
Can Liu, Ji-Deng Ma, Jin-Wei Zhang, H. Zhao, Yan Zhu, Jing Qi, Lingyan Liu, Li Zhu, Yan-Zhi Jiang, G. Tang, Xue-Wei Li, Ming-Zhou Li   +11 more
semanticscholar   +1 more source

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

Association of Testosterone With Lean Soft Tissue and Handgrip Strength Across Middle‐Aged Men

Journal of Cachexia, Sarcopenia and Muscle
Background Testosterone declines by 0.4%–2% annually after the age of 30 and is potentially linked with muscle mass and strength. This study examined how testosterone levels are associated with handgrip strength (HGS) and appendicular lean soft tissue ...
Konstantinos Prokopidis, Stefano Cacciatore, Joseph McLean, Paolo Piaggi, Carla M. Prado, John A. Batsis, Mathias Schlögl   +6 more
doaj   +1 more source

Metabolic Disorders and Male Hypogonadotropic Hypogonadism

Frontiers in Endocrinology, 2019
Several studies highlight that testosterone deficiency is associated with, and predicts, an increased risk of developing metabolic disorders, and, on the other hand, is highly prevalent in obesity, metabolic syndrome and type-2 diabetes mellitus.
Rosario Pivonello, Davide Menafra, Enrico Riccio, Francesco Garifalos, Marco Mazzella, Cristina de Angelis, Annamaria Colao   +6 more
doaj   +1 more source

British Society for Sexual Medicine Guidelines on Adult Testosterone Deficiency, With Statements for UK Practice.

Journal of Sexual Medicine, 2017
BACKGROUND Testosterone deficiency (TD) is an increasingly common problem with significant health implications, but its diagnosis and management can be challenging.
G. Hackett, M. Kirby, D. Edwards, T. Jones, K. Wylie, N. Ossei-Gerning, J. David, A. Muneer   +7 more
semanticscholar   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular disease in men with low testosterone

, 2017
Introduction: Testosterone deficiency increases the cardiovascular disease (CVD) risk. ;Aim: To evaluate the effect of erectile dysfunction (ED), sexual frequency and hypogonadal symptoms on CVD risk.
Ho, Chen-Hsun;Wu, Chia-Chang;Chen, Kuan-Chou;Jaw, Fu-Shan;Yu, Hong-Jeng;Liu, Shih-Ping, 余宏政;劉詩彬;趙福杉   +1 more
core   +1 more source

Unbound Intrinsic Formation Clearance of 6β‐Hydroxycortisol Is a Useful Biomarker of CYP3A4 Activity during Pregnancy

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy results in multiple physiological changes that impact drug disposition. For example, hepatic CYP3A activity and renal transporter‐mediated clearance increase in late pregnancy, but the time course of these changes across pregnancy is not known.
Aurora K Authement, Mary F Hebert, Emily E Fay, Nina Isoherranen   +3 more
wiley   +1 more source

Testosterone deficiency in non-cancer opioid-treated patients

Journal of Endocrinological Investigation, 2018
PurposeThe use of opioids in patients with chronic non-cancer pain is common and can be associated with opioid-induced androgen deficiency (OPIAD) in men.
F. Coluzzi, D. Billeci, M. Maggi, G. Corona   +3 more
semanticscholar   +1 more source

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core