Results 71 to 80 of about 40,621 (188)

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Testosterone Deficiency, Long-Term Testosterone Therapy, and Cardiovascular Risk: A Longitudinal Study

, 2021
Cardiovascular disease is the major cause of morbidity and the leading cause of death globally. As compared to women, men have a higher cardiovascular risk. Recent studies suggest that testosterone as it is the most abundant male hormone plays a critical
Zhang, Xiao
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Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome.

PLoS ONE, 2013
ObjectiveThe association between type 2 diabetes and low testosterone has been well recognized. However, testosterone levels in men with prediabetes have been rarely reported.
Chen-Hsun Ho, Hong-Jeng Yu, Chih-Yuan Wang, Fu-Shan Jaw, Ju-Ton Hsieh, Wan-Chung Liao, Yeong-Shiau Pu, Shih-Ping Liu   +7 more
doaj   +1 more source

Testosterone deficiency in male: a risk factor for heart failure

, 2013
Testosterone deficiency syndrome (TDS) induces several negative effects that generally involve different organs such as testis, bone, skeletal muscle, and heart, leading to reduction in testis function, causing osteoporosis, strongly reducing muscle mass,
GUASTAMACCHIA, Edoardo, Guastamacchia E, Giagulli VA, Triggiani V, Iacoviello M, De Pergola G, DE PERGOLA, Giovanni, TRIGGIANI, Vincenzo   +7 more
core   +1 more source

Deficient testosterone levels in men above 45 years with major depressive disorder - an age-matched case control study

South African Journal of Psychiatry, 2007
Background. Symptoms of partial androgen deficiency in ageing men (PADAM) overlap considerably with those of major depressive disorder. The relationship between these conditions is complicated by the usual age-related decline in serum testosterone ...
A M Dikobe, C W van Staden, S Reif, M Bornman   +3 more
doaj   +1 more source

Testosterone deficiency and dietary therapeutic interventions in the rat model of diet-induced metabolic syndrome [PDF]

, 2014
Male Wistar rats fed with high carbohydrate (68%) and high fat (24%) diet (H) mimicking 'Western diets' showed enhanced visceral obesity and its associated risk factors of metabolic syndrome such as impaired glucose utilisation, insulin resistance ...
Kumar, Senthil Arun
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Subcutaneous Leydig Stem Cell Autograft: A Promising Strategy to Increase Serum Testosterone

Stem Cells Translational Medicine, 2019
Exogenous testosterone therapy can be used to treat testosterone deficiency; however, it has several adverse effects including infertility due to negative feedback on the hypothalamic–pituitary–gonadal (HPG) axis.
Himanshu Arora, Marilia Sanches Santos Rizzo Zuttion, Bruno Nahar, Dolores Lamb, Joshua M. Hare, Ranjith Ramasamy   +5 more
doaj   +1 more source

Remission of type 2 diabetes and pleiotropic effects of long-term testosterone treatment for “late-onset” hypogonadism: A case report

SAGE Open Medical Case Reports, 2019
For obese type 2 diabetes patients, weight reduction is one of the most important measures but fails in most cases. Testosterone deficiency can be the reason for such failure.
Ahmad Haider, Karim Haider, Farid Saad, Markolf Hanefeld   +3 more
doaj   +1 more source

Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in Men with Testosterone Deficiency Syndrome

, 2016
Purpose: We aimed to evaluate the effect of testosterone replacement therapy (TRT) on cognitive function and depression in men with testosterone deficiency syndrome.
Hyun Jin Jung, Hong Seok Shin
core   +1 more source

Testosterone replacement therapy for older men

, 2008
Stephen E Borst, Thomas MulliganGeriatrics Research, Education, and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USAAbstract: Despite intensive research on testosterone therapy for older men, important questions ...
Stephen E Borst, Thomas Mulligan
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