Results 71 to 80 of about 1,739,242 (280)

Testosterone Deficiency.

Journal of the American Medical Association (JAMA), 2019
Testosterone is important for muscle mass, bone strength, hair growth, and sexual function. Low testosterone can cause symptoms such as low energy, poor concentration, depression, low libido, and erectile dysfunction.
J. Halpern, R. Brannigan
semanticscholar   +1 more source

Testosterone Deficiency and Risk of Cognitive Disorders in Aging Males

The World Journal of Men's Health, 2020
Cognitive impairment and dementia are predicted to undergo a dramatic increase in the following years with more than 131.5 million people being affected by 2030.
G. Corona, F. Guaraldi, G. Rastrelli, A. Sforza, M. Maggi   +4 more
semanticscholar   +1 more source

The relationship of salivary testosterone and male sexual dysfunction in opioid-associated androgen deficiency (OPIAD) [PDF]

, 2016
The relationship of salivary testosterone and male sexual dysfunction in opioid-associated androgen deficiency ...
Alfayate, Rocío, Sánchez Barbié, Ángel, Peiró, Ana M., Segura, Ana, Ajo Ferrer, Raquel, inda, maria-del-mar, Margarit, César, Mira, Laura   +7 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

An Overview of Testosterone Therapy

American Journal of Men's Health, 2016
Millions of men, as a result of the natural aging process, injury, illness, and medical therapies, experience a decline in testosterone levels that necessitate a need for testosterone supplementation therapy (TST).
O. Danny Lee PhD, APRN-BC, CNE, Ken Tillman PhD, RN   +1 more
doaj   +1 more source

Associations of Endogenous Testosterone and Lipid Profiles in Middle-Aged to Older Taiwanese Men

, 2012
The relationship between endogenous plasma testosterone and plasma lipids was assessed among 856 Taiwanese men >= 40 years old originally recruited for an epidemiological study of testosterone deficiency syndrome. Blood samples were drawn from fasting n =
JIANN, BANG-PING;HSIEH, JU-TON;LIU, SHIH-PING;WU, HSI-CHIN, 簡邦平;謝汝敦;劉詩彬;吳錫金   +1 more
core   +1 more source

The VCPIP1‐UBE3A Deubiquitination‐Ubiquitination Cascade Contributes to Castration‐Resistant Prostate Cancer Progression

Advanced Science, EarlyView.
VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin, Wen‐Cai Zheng, Yi‐Qiu Wang, Bin Lin, Yun‐Zhi Lin, Dong‐Ning Chen, Xiao‐Dong Li, Xue‐Yi Xue, Yong Wei, Ning Xu   +9 more
wiley   +1 more source

Prevalence of testosterone deficiency among aging men with and without morbidities

The Aging Male, 2019
In this cross-sectional study 1852 men aged 40–70 years attending primary health care were invited to fill out the aging male symptoms (AMS) scale. Out of these, 1222 men were found positive for the AMS and agreed to provide blood samples for the general
J. Ērenpreiss, V. Fodina, Rita Požarska, Ksenija Zubkova, Alesja Dudorova, A. Požarskis   +5 more
semanticscholar   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Testosterone and androstenedione concentrations in human testis and epididymis during the first two years of life [PDF]

, 1983
Testosterone and androstenedione were measured in testicular and epididymal tissue of 37 previously healthy infants between 1 and 24 months of age who died suddenly. In half of the patients elevated plasma levels of cortisol and androstenedione suggested
Eisenmenger, Wolfgang, Dörr, H. G., Bidlingmaier, F., Kuhnle, U., Knorr, D.   +4 more
core   +1 more source