Results 61 to 70 of about 40,879 (288)

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Testosterone Deficiency, Long-Term Testosterone Therapy, and Cardiovascular Risk: A Longitudinal Study [PDF]

, 2021
Cardiovascular disease is the major cause of morbidity and the leading cause of death globally. As compared to women, men have a higher cardiovascular risk. Recent studies suggest that testosterone as it is the most abundant male hormone plays a critical
Zhang, Xiao
core  

COMPARATIVE ANALYSIS OF CLINICAL CHRONIC BACTERIAL PROSTATITIS IN PATIENTS WITH DEFICIENCY AND NORMAL TESTOSTERONE LEVELS

Вестник урологии, 2013
The study included a survey of 42 patients with chronic bacterial prostatitis. Depending on the level of total testosterone, patients were divided into two groups : I group – 20 patients whose serum total testosterone was below the standard ratio (8-12 ...
A. A. Chernyj, M. I. Kogan, H. S. Ibishev   +2 more
doaj   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

Additive damage in the thromboxane related vasoconstriction and bradykinin relaxation of intramural coronary resistance arterioles in a rodent model of andropausal hypertension

Heliyon, 2022
Hypertension and andropause both accelerate age–related vascular deterioration. We aimed to evaluate the effects of angiotensin-II induced hypertension and deficiency of testosterone combined regarding the resistance coronaries found intramurally.Four ...
Attila Jósvai, Marianna Török, Judit Hetthéssy, Máté Mátrai, Anna Monori-Kiss, Jennifer Makk, Márton Vezér, Levente Sára, István Szabó, Béla Székács, György L. Nádasy, Szabolcs Várbíró   +11 more
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes [PDF]

, 2014
Communication between organs and tissues is predominately controlled by hormones. Hormones regulate a vast variety of physiological and behavioural activities, including metabolism, growth and development, reproduction, sleep and mood.
Fürstenberger, Cornelia
core   +1 more source

Serum PSA as a Predictor of Testosterone Deficiency

The Journal of Sexual Medicine, 2013
ABSTRACT Introduction The relationship between serum prostate-specific antigen (PSA) and testosterone (T) levels is still controversial. According to the “saturation hypothesis,” a significant relationship is apparent only in the low T range. Aim
RASTRELLI, GIULIA, Corona G, VIGNOZZI, LINDA, Maseroli E, Silverii A, Monami M, MANNUCCI, EDOARDO, FORTI, GIANNI, MAGGI, MARIO   +8 more
openaire   +2 more sources

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Testosterone deficiency in male: a risk factor for heart failure [PDF]

, 2013
Testosterone deficiency syndrome (TDS) induces several negative effects that generally involve different organs such as testis, bone, skeletal muscle, and heart, leading to reduction in testis function, causing osteoporosis, strongly reducing muscle mass,
GUASTAMACCHIA, Edoardo, Guastamacchia E, Giagulli VA, Triggiani V, Iacoviello M, De Pergola G, DE PERGOLA, Giovanni, TRIGGIANI, Vincenzo   +7 more
core   +1 more source