Results 91 to 100 of about 12,744 (284)

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

A randomised comparison evaluating changes in bone mineral density in advanced prostate cancer: luteinising hormone-releasing hormone agonists versus transdermal oestradiol. [PDF]

, 2015
BACKGROUND: Luteinising hormone-releasing hormone agonists (LHRHa), used as androgen deprivation therapy (ADT) in prostate cancer (PCa) management, reduce serum oestradiol as well as testosterone, causing bone mineral density (BMD) loss.
Abel, PD, Abel, RL, Alhasso, AA, Cafferty, F, Carpenter, R, Duong, T, Honeyfield, L, Jovic, G, Kynaston, HG, Langley, RE, Paez, EM, Parmar, MK, Robertson, A, Scrase, CD, Stone, M, Welland, A   +15 more
core   +2 more sources

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery

Neuroprotection, EarlyView.
Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher, Anna F. Dominiczak, Luis M. Garcia‐Segura, Nobuhiro Harada, J. B. Hutchison, James M. Mullin, Delyth Graham, Peter O'Shaughnessy, Hilary Victoria O. Carswell   +8 more
wiley   +1 more source

Reduced‐Frequency GLP1 Therapy Maintains Weight, Body Composition, and Metabolic Syndrome Improvements: A Case Series

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate whether reduced‐frequency dosing of GLP1 receptor agonists maintains weight loss, body composition, and metabolic syndrome improvements following successful initial treatment with standard weekly therapy. Methods This retrospective case series included 30 adults who achieved weight plateau while on weekly
Michelle Wong, Ash Wu, Pawanjot K. Garhe, Mitch Biermann   +3 more
wiley   +1 more source

Transdermal evaluation of caffeine in different formulations and excipients [PDF]

, 2013
Background: The stratum corneum(SC) forms adifficultphysical barrier fordrugs to pass through the skin. Several strategieswere developed to overcome this barrier.Optimization of topical drug formulations by selected excipients may facilitate the ...
Boonen, Jente, Burvenich, Christian, De Spiegeleer, Bart, Mehuys, Els, Peremans, Kathelijne, Remon, Jean Paul, Roche, Nathalie, Veryser, Lieselotte   +7 more
core   +2 more sources

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Autonomic arousal and attentional orienting to visual threat are predicted by awareness [PDF]

, 2015
The rapid detection and evaluation of threat is of fundamental importance for survival. Theories suggest that this evolutionary pressure has driven functional adaptations in a specialized visual pathway that evaluates threat independently of conscious ...
Adams, W. J., Garner, M., Hedger, N.
core   +2 more sources

Impact of the Nadir Androgen Receptor Signaling Inhibitor‐Derived Integrative Response Model in Real‐World Patients With Metastatic Castration‐Sensitive Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background Early deep prostate‐specific antigen (PSA) decline after the initiation of androgen receptor signaling inhibitor (ARSI) therapy is associated with favorable long‐term outcomes in metastatic castration‐sensitive prostate cancer (mCSPC).
Kazuma Yukihiro, Yohei Sekino, Keisuke Goto, Kohei Saito, Kenta Fujiyama, Yoshito Kagiyama, Yoshimasa Kurimura, Kenichiro Fukuoka, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata   +14 more
wiley   +1 more source

Effects of the social environment during adolescence on the development of social behaviour, hormones and morphology in male zebra finches (Taeniopygia guttata) [PDF]

, 2017
Background Individual differences in behaviour are widespread in the animal kingdom and often influenced by the size or composition of the social group during early development.
A Bandura, A Guenther, AE Jones, AM Dunn, AS Gersick, B Buwalda, B Silverin, BA Schlinger, BG Galef, C Arnold, C Ferris, C Scharff, CB Sturdy, CF Harding, CK Catchpole, CL Ralph, CL Sisk, CL Sisk, D Aronov, DJ White, E Adkins-Regan, E Adkins-Regan, E Adkins-Regan, E Choleris, E Pröve, EC Perez, ED Nottelmann, GR Brown, H Goldstein, H Williams, HJ Bischof, I Branchi, JC Wingfield, JC Wingfield, JC Wingfield, JC Wommack, JG Vandenbergh, JL Miller, JP Curley, K Immelmann, K Immelmann, K Siegeler, K Spencer, KA Spencer, KJ McGraw, KL Field, KM Schulz, L Remage-Healey, LA Eales, LF Sundström, LM Pyter, LP Spear, M Honarmand, M Naguib, M Romero, M Romero, MB Hennessy, MB Hennessy, MJ Meaney, MJ West, MM Mariette, MM Mariette, N Perfito, N Perfito, N Perfito, N Sachser, N Sachser, N Sachser, Nikolaus von Engelhardt, NS Clayton, O Tchernichovski, P Martin, PJB Slater, R Sossinka, RA Zann, RG Morrison, S Harvey, S Kaiser, S Lürzel, S Lürzel, S Lürzel, SA Collins, SB Banerjee, SB Banerjee, SJ Blakemore, Stefanie Bölting, SW Bottjer, T Ruploh, T Ruploh, T Ruploh, TM Freeberg, W Goymann, WD Odell, Y Delville, Y Delville   +94 more
core   +2 more sources

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source