Results 121 to 130 of about 16,122 (268)

Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt‐Dependent NAD+ De Novo Synthesis in Mice

Aging Cell, EarlyView.
In Qprt‐deficient mice, testicular NAD+ levels decline accelerated with age, leading to mitochondrial dysfunction, disrupted DSB repair, impaired meiotic sex chromosome inactivation, and germ cell loss. Nicotinamide riboside (NR) supplementation restores NAD+ levels and alleviates these defects, highlighting the importance of NAD+ de novo synthesis in ...
Yining Xu, Huan Wang, Hui Li, Chenlu Wei, Zhenye Zhu, Yanqing Zhao, Jiajia Zhu, Min Lei, Yingpu Sun, Qingling Yang   +9 more
wiley   +1 more source

A Single‐Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging

Aging Cell, EarlyView.
This study utilized single‐cell RNA sequencing to analyze immune cells in 33 human testis samples (ages 21–69). We found age‐related alterations in monocytes and MRC1hi TRM, with shifts in phagocytosis, cytokine, and antigen presentation, contributing to low‐grade inflammation in aging. These findings provide insights into immune aging in human testis.
Qiaoling Jiang, Lina Cui, Xichen Nie, Hui Cai, Wenxiu Zhang, Xiaojian Lu, Yifei Guo, James M. Hotaling, Bradley R. Cairns, Xiaoyan Wang, Jingtao Guo   +10 more
wiley   +1 more source

Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study

Aging Cell, EarlyView.
Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.
Tianzhichao Hou, Zimo Sha, Qi Wang, Yuanyue Zhu, Zheng Zhu, Huajie Dai, Yijie Zhu, Tiange Wang, Mian Li, Zhiyun Zhao, Yu Xu, Jieli Lu, Jie Zheng, Jing Ye, Weiqing Wang, Guang Ning, Yufang Bi, Weiguo Hu, Min Xu   +18 more
wiley   +1 more source

The function of the pituitary‐testicular axis in dogs prior to and following surgical or chemical castration with the GnRH‐agonist deslorelin

Reproduction in Domestic Animals, Volume 58, Issue 1, Page 97-108, January 2023., 2023
Abstract Chemical castration, that is the reduction of circulating testosterone concentrations to castrate levels by administration of a GnRH‐agonist implant, is a popular alternative to surgical castration in male dogs. Detailed information concerning the pituitary‐testicular axis following administration of a GnRH‐agonist implant is still scarce ...
Annemarie Spruijt, Hans Kooistra, Christine Oei, Claudia Vinke, Auke Schaefers‐Okkens, Jeffrey De Gier   +5 more
wiley   +1 more source

Medication experiences in the treatment of opioid use disorders: Insights from Reddit

Addiction, EarlyView.
Abstract Background and Aims Better understanding the challenges faced by patients on medications for opioid use disorder (MOUD), including methadone and buprenorphine, is critical to increasing their use/retention. Social media platforms such as Reddit offer a space for patients to share their experiences with medications.
Alexandra Almeida, Mike Conway, David J. Grelotti, Amarnath Gupta, David Frank, Annick Bórquez   +5 more
wiley   +1 more source

All Patches Matter, More Patches Better: Enhance AI-Generated Image Detection via Panoptic Patch Learning [PDF]

arXiv
The exponential growth of AI-generated images (AIGIs) underscores the urgent need for robust and generalizable detection methods. In this paper, we establish two key principles for AIGI detection through systematic analysis: \textbf{(1) All Patches Matter:} Unlike conventional image classification where discriminative features concentrate on object ...
arxiv  

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Evaluation of dimethandrolone undecanoate in non‐human primates as a candidate for long‐acting injectable male contraceptive

Andrology, EarlyView.
Abstract Background Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions.
Deborah I. Bunin, Kyuri Kim, Toufan Parman, Janet Gahagen, Mary B. Zelinski, Tiffany Adevai, Christina Wang, Liang Tang, Lalitha Iyer, Aaron Endsley, Diana L. Blithe, Min S. Lee   +11 more
wiley   +1 more source

Chemometrics-aided Surface-enhanced Raman spectrometric detection and quantification of GH and TE hormones in blood [PDF]

arXiv
This work explores the use of Surface-Enhanced Raman Spectroscopy (SERS) combined with artificial neural network (ANN) models to detect and quantify growth hormone (GH) and testosterone (TE) in the blood of Sprague Dawley (SD) rats. SERS spectra were recorded from blood samples of SD rats injected with GH, TE, both hormones, and non-injected controls ...
arxiv