Results 121 to 130 of about 563,660 (283)

Testosterone Hormone Replacement Therapy: State-of-the-Art and Emerging Technologies [PDF]

, 2018
In the human male, testosterone is the major circulating androgen. The clinical effects of androgen are numerous, and testosterone deficiency is associated with a number of clinical abnormalities.
Guy, Richard, Leichtnam, Marie-Laure, Rolland, Hervé, Wüthrich, Patrick   +3 more
core  

Colour Morphs as Alternative Solutions to the Trade‐Off Predicted by the Immuno‐Competence Handicap Hypothesis

Integrative Zoology, EarlyView.
In this study, we tested whether white and yellow morphs of the common wall lizard (Podarcis muralis) adopt alternative strategies shaped by the immuno‐competence handicap hypotheses (ICHH). We found that testosterone‐induced immune suppression was stronger in white males, while aggression decreased in both morphs.
Roberto Sacchi, Alan J. Coladonato, Stefano Scali, Marco A. L. Zuffi, Rupert Palme, Marco Mangiacotti   +5 more
wiley   +1 more source

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

Aging Cell, EarlyView.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang, Jordan Teoli, Benjamin Rey, Cristina Vieira, Jean‐François Lemaitre, Ingrid Plotton, Gabriel A. B. Marais, Steve Horvath   +7 more
wiley   +1 more source

Testosterone Enhances KV Currents and Airway Smooth Muscle Relaxation Induced by ATP and UTP through P2Y4 Receptors and Adenylyl Cyclase Pathway

International Journal of Molecular Sciences
Numerous studies suggest the involvement of adenosine-5′-triphosphate (ATP) and similar nucleotides in the pathophysiology of asthma. Androgens, such as testosterone (TES), are proposed to alleviate asthma symptoms in young men.
Abril Carbajal-García, J. Reyes-García, V. Díaz-Hernández, María F Casas-Hernández, F. Flores-Murrieta, Luis M. Montaño   +5 more
semanticscholar   +1 more source

DEFENDING ALL-MALE EDUCATION: A NEW CULTURAL MOMENT FOR A RENEWED DEBATE [PDF]

, 2001
Although all-female schools still prosper and are defended by members of the academic elite, an all-male college has become a near-extinct species. Many people are surprised such a creature still exists.
Webb, Stephen H.
core   +1 more source

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy

Aging Cell, EarlyView.
Post‐menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre‐menopausal (< 40 years) females. Hormone Replacement Therapy (HRT) use in menopausal females (44–60 years) decreases the frequency of inflammatory monocytes and improves phagocytosis as compared to age ...
R. P. H. De Maeyer, J. Sikora, O. V. Bracken, B. Shih, A. F. Lloyd, H. Peckham, K. Hollett, K. Abdelhamid, W. Cai, M. James, P. E. Pfeffer, M. Vukmanovic‐Stejic, A. N. Akbar, E. S. Chambers   +13 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Cardiac function and coronary plaque development following masculinizing gender‐affirming hormone therapy: A prospective cohort study

Andrology, EarlyView.
Abstract Introduction Myocardial dysfunction and the presence of calcified and non‐calcified coronary plaques are predictors of cardiovascular disease. Masculinizing gender‐affirming hormone therapy may increase cardiovascular risk, highlighting the need for prospective studies to evaluate cardiovascular outcomes during gender‐affirming hormone therapy.
Laust Frisenberg Buhl, Marianne S. Andersen, Jan Frystyk, Axel Diederichsen, Selma Hasific, Rikke Hjortebjerg, Jordi Sanchez Dahl, Manijeh Noori, Kirstine Nørregaard Hansen, Gitte Maria Jørgensen, Camilla Viola Palm, Tine Taulbjerg Kristensen, Dorte Glintborg, Louise Lehmann Christensen   +13 more
wiley   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Effects of glucagon‐like peptide 1 receptor agonists on testicular dysfunction: A systematic review and meta‐analysis

Andrology, EarlyView.
Abstract Background Hypogonadism and infertility are two conditions that are heavily affected by overweight and obesity in the male patient. Glucagon‐like peptide 1 agonists (GLP‐1RAs) are a recently introduced class of antidiabetic drugs with powerful weight‐loss effect; this may induce an indirect positive effect on the testicular function ...
Gianmaria Salvio, Alessandro Ciarloni, Nicola Ambo, Monia Bordoni, Michele Perrone, Silvia Rossi, Giancarlo Balercia   +6 more
wiley   +1 more source