Results 21 to 30 of about 20,312 (267)

Contrast‐enhanced micro‐computed tomography of compartment and time‐dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis

The Anatomical Record, Volume 306, Issue 1, Page 92-109, January 2023., 2023
Abstract A lack of understanding of the mechanisms underlying osteoarthritis (OA) progression limits the development of effective long‐term treatments. Quantitatively tracking spatiotemporal patterns of cartilage and bone degeneration is critical for assessment of more appropriately targeted OA therapies.
Deva D. Chan, Maleeha Mashiatulla, Jun Li, Ryan D. Ross, Meghana Pendyala, Amit Patwa, Mark W. Grinstaff, Anna Plaas, D. Rick Sumner   +8 more
wiley   +1 more source

Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models

BJUI Compass, Volume 4, Issue 1, Page 44-58, January 2023., 2023
Abstract Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. However, a lack of rigorously conducted prospective studies has stalled clinical use in this setting.
Nan Fang Wang, Toni Rose Jue, Jeff Holst, Jennifer H. Gunter   +3 more
wiley   +1 more source

Intrinsa: testosterone patch for low sexual desire in women [PDF]

Prescriber, 2008
AbstractIntrinsa, a transdermal testosterone patch, is licensed for women with hypoactive sexual desire disorder following bilateral oophorectomy or hysterectomy. Here, Steve Chaplin presents the clinical data relating to its efficacy and adverse effects, and Mr Panay comments on its role in therapy.
Nick Panay, Steve Chaplin
openaire   +2 more sources

The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay

ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022
The adipokine chemerin and the short peptide agonist chemerin‐9 activate two GPCRs: CMKLR1 and GPR1. Here, we established a nanoluciferase based binding assay to analyze differences in ligand binding. For GPR1, both ligands show high affinity and comparable binding.
Anne Sophie Czerniak, Kevin Kretschmer, Tina Weiß, Annette G. Beck‐Sickinger   +3 more
wiley   +1 more source

Attractive and healthy-looking male faces do not show higher immunoreactivity

Scientific Reports, 2022
Previous research has indicated that facial attractiveness may provide cues to the functioning of the immune system. Mating with individuals who have a more effective immune system could lead to a higher reproductive success.
Žaneta Pátková, Dagmar Schwambergová, Jitka Třebická Fialová, Vít Třebický, David Stella, Karel Kleisner, Jan Havlíček   +6 more
doaj   +1 more source

The effect of estroprogestagen therapy on lipid status in menopause depending on the drug administration route [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. In menopausal women lipid and lipoprotein values are important predictors of development of cardiovascular diseases (CVD). The use of estrogens reduces levels of low density lipoprotein cholesterol (LDLC) and lipoprotein A [Lp(a)], and ...
Čitlučanin Goran, Ivović Miomira, Tančić-Gajić Milina, Canović Fadil, Stojanović Miloš, Marina Ljiljana, Arizanović Zorana, Đogo Aleksandar, Gerginić Vladimir, Vujović Svetlana   +9 more
doaj   +1 more source

Sexually selected male plumage color is testosterone dependent in a tropical passerine bird, the red-backed fairy-wren (Malurus melanocephalus). [PDF]

PLoS ONE, 2011
BACKGROUND: Sexual signals, such as bright plumage coloration in passerine birds, reflect individual quality, and testosterone (T) may play a critical role in maintaining signal honesty.
Willow R Lindsay, Michael S Webster, Hubert Schwabl   +2 more
doaj   +1 more source

Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

Frontiers in Pharmacology, 2022
Buprenorphine (BUP) is a potent opioid analgesic that is widely used for severe pain management and opioid replacement therapy. The oral bioavailability of BUP, however, is significantly limited by first-pass metabolism.
Tim Quach, Luojuan Hu, Sifei Han, Shea F. Lim, Danielle Senyschyn, Preeti Yadav, Natalie L. Trevaskis, Jamie S. Simpson, Christopher J. H. Porter   +8 more
doaj   +1 more source

The testosterone patch for women [PDF]

International Journal of Impotence Research, 2005
Has the FDA discriminated against female sexual dysfunction by not endorsing Procter & Gamble's (P&G) Intrinsa? Has the pendulum swung so far to the right that drugs for sexual medicine receive undue scrutiny? Why is testosterone replacement therapy available for men, but not for women? How should the pharmaceutical industry proceed with future studies?
openaire   +3 more sources

Myocarditis following COVID‐19 vaccine: incidence, presentation, diagnosis, pathophysiology, therapy, and outcomes put into perspective. A clinical consensus document supported by the Heart Failure Association of the European Society of Cardiology (ESC) and the ESC Working Group on Myocardial and Pericardial Diseases

European Journal of Heart Failure, Volume 24, Issue 11, Page 2000-2018, November 2022., 2022
Overview on incidence, diagnosis, and therapy in vaccine‐related myocarditis. CMR, cardiac magnetic resonance; EMB, endomyocardial biopsy; NSAIDS, non‐steroidal anti‐inflammatory drugs. Abstract Over 10 million doses of COVID‐19 vaccines based on RNA technology, viral vectors, recombinant protein, and inactivated virus have been administered worldwide.
Bettina Heidecker, Noa Dagan, Ran Balicer, Urs Eriksson, Giuseppe Rosano, Andrew Coats, Carsten Tschöpe, Sebastian Kelle, Gregory A. Poland, Andrea Frustaci, Karin Klingel, Pilar Martin, Joshua M. Hare, Leslie T. Cooper, Antonis Pantazis, Massimo Imazio, Sanjay Prasad, Thomas F. Lüscher   +17 more
wiley   +1 more source