On the importance of including both sexes in animal studies – insights from home‐cage monitoring
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Metabolic Effects of Testosterone Replacement Therapy in Men with Functional Secondary Hypogonadism, Obesity and Type 2 Diabetes or Metabolic Syndrome: A Systematic Review. [PDF]
Ntais C +2 more
europepmc +1 more source
An integrated network pharmacology, chemical profiling, molecular docking, molecular dynamics, and in vivo strategy shows that Modified Huanglian Wendan Decoction improves reproductive and metabolic abnormalities in a rat model of PCOS with insulin resistance.
Xi Chen +4 more
wiley +1 more source
Oncological Safety of Testosterone Replacement Therapy in Men With a History of Prostate Cancer: A Systematic Review. [PDF]
Alexandre Alves VA +7 more
europepmc +1 more source
ABSTRACT In patients with a remote history of traumatic brain injury, central adrenal insufficiency may remain unrecognized for decades. An apparently adequate response to standard‐dose ACTH stimulation should not preclude further evaluation of the hypothalamic–pituitary–adrenal axis when clinical and biochemical findings continue to suggest adrenal ...
Kazunori Kageyama +5 more
wiley +1 more source
Testosterone Replacement Therapy in Women Is Associated with Improved Symptom Burden and Favorable Biomarker Changes: A Retrospective Observational Study. [PDF]
Elggren CW +9 more
europepmc +1 more source
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee +5 more
wiley +1 more source
Secondary Hypogonadism and Effects of Testosterone Replacement Therapy on Cardiovascular Events.
Munro V, Law J, Matheson K, Imran SA.
europepmc +1 more source
A Guide for the Inclusion of Sex and Gender Considerations in Clinical Practice Guidelines
ABSTRACT Despite increasing understanding of sex and gender as important determinants of health, there has been a lack of consideration regarding sex, gender, and other intersectional factors in clinical practice guidelines (CPGs) to date, and little support for guideline developers to address these shortcomings.
Tania King +6 more
wiley +1 more source
Injectable Testosterone Replacement Therapy Within 1 Year Before ACL Reconstruction Is Associated With Increased Revision Rates. [PDF]
Stickels MW +5 more
europepmc +1 more source

