Evaluating Reproductive Health Recommendations in CPGs for Sickle Cell Disease: An Umbrella Review
Clinical and Public Health Guidelines, Volume 3, Issue 4, October 2026.ABSTRACT Background Individuals with sickle cell disease or trait (SCD/T) face significant reproductive health risks, highlighting the need to assess the best available evidence on their reproductive health needs. Objectives To assess the quality of SCD/T clinical practice guidelines and evaluate the key characteristics and quality of their ...
Lisa R. Roberts +4 more
wiley +1 more source
Health Economics, Volume 35, Issue 10, Page 1468-1481, October 2026.ABSTRACT Gender incongruence in trans and nonbinary (“trans”) populations is often associated with psychological distress and increased demand for mental healthcare. Gender‐affirming hormone therapy (GAHT) is a key component of care for many trans people, yet long‐term evidence around its cost implications remains limited despite increasing uptake and ...
Karinna Saxby +2 more
wiley +1 more source
Self-Referred Late-Onset Hypogonadism Hypothesis and Testosterone Replacement Therapy in Major Depressive Disorder Under Polypharmacy: A Case Report. [PDF]
CureusIchino K, Okui N, Ide H, Horie S.
europepmc +1 more source
A cross-sectional survey of experiences and outcomes of using testosterone replacement therapy in UK men. [PDF]
Transl Androl UrolEl-Osta A +6 more
europepmc +2 more sources
Iron and Other Metal Ions in Human Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley +1 more source
The relationship between testosterone replacement therapy and incidence of proximal humerus fractures in men: a matched retrospective analysis. [PDF]
JSES Rev Rep TechArcand PH +8 more
europepmc +1 more source
Andrology, Volume 14, Issue 7, Page 1971-1987, October 2026.ABSTRACT Background Male hypogonadotropic hypogonadism typically presents with azoospermia and is one of the few causes of infertility amenable to a medical intervention. Gonadotropin therapy offers a chance to restore spermatogenesis and fertility in these individuals.
Manou Huijben +3 more
wiley +1 more source
Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines
Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede +11 more
wiley +1 more source
Cardiovascular Effects of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review of Lipid Profiles, Inflammatory Markers, and Vascular Function. [PDF]
CureusEzeamii PC +9 more
europepmc +1 more source
Cancer Science, Volume 117, Issue 10, Page 2769-2789, October 2026.ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei +9 more
wiley +1 more source