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Testosterone replacement therapy
British Journal of Hospital Medicine, 2007Hypgonadism has important adverse effects on the health and quality of life of affected men, but remains underdiagnosed in clinical practice. This article reviews the physiology, causes and diagnosis of hypogonadism and the potential benefits of treatment with testosterone replacement therapy
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Testosterone replacement therapy
Medicine, 2009Abstract Testosterone replacement therapy is a well-tolerated and established treatment for hypogonadism, providing excellent clinical and biochemical relief from the effects of sex steroid deficiency. This review gives a practical clinical guide to managing testosterone replacement therapy.
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Pharmacogenetics of Testosterone Replacement Therapy
Pharmacogenomics, 2009Variable phenotypes of androgen insensitivity exist in humans, mainly owing to defective, mutated androgen receptors. A more subtle modulation of androgen effects is related to the CAG repeat polymorphism ([CAG]n) in exon 1 of the androgen receptor gene, in vitro, transcription of androgen-dependent target genes is attenuated with increasing length of ...
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Testosterone Replacement Therapy and Prostate Health
Current Urology Reports, 2012There is an emerging evolution in the understanding of the relationship between the prostate and testosterone. It has long been generally believed that with testosterone replacement therapy (TRT), increasing serum testosterone levels led to prostatic growth and worsening of voiding dysfunction and associated complications.
A Scott, Polackwich +2 more
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Hormone Therapy: Testosterone Replacement Therapy.
FP essentials, 2023Testosterone levels decrease as men age. When the testes fail to produce an adequate level of endogenous testosterone, men develop hypogonadism. Although the definition of a low testosterone level varies among guidelines, a serum total testosterone level of less than 300 to 350 ng/dL on two separate morning blood samples is considered a low level.
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Advances in Testosterone Replacement Therapy
2008The major goal of androgen substitution is to replace testosterone at levels as close to physiological concentrations as is possible. The mainstay of testosterone susbstitution are parenteral testosterone esters (enanthate and cypionate) to be administered every 2-3 weeks.
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Blood donation and testosterone replacement therapy
Transfusion, 2017BACKGROUNDPolycythemia is the most common adverse effect of testosterone replacement therapy (TRT) and may predispose patients to adverse vascular events. Current Canadian guidelines recommend regular laboratory monitoring and discontinuing TRT or reducing the dose if the hematocrit exceeds 54% (hemoglobin ≥180 g/L). This threshold has been interpreted
Benjamin, Chin-Yee +4 more
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Testosterone Replacement Therapy in Deficient Patients With Chronic Heart Failure
Journal of Cardiovascular Pharmacology and Therapeutics, 2018Background: Testosterone deficiency is associated with heart failure (HF) progression and poor prognosis. Testosterone therapy has been shown to improve exercise capacity in patients with chronic HF, but no trial has evaluated the impact of replacement ...
M. Navarro-Peñalver +10 more
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Testosterone replacement therapy in male hypogonadism
Journal of Endocrinological Investigation, 2003In human males 6-7 mg of testosterone are secreted by the testes in a circadian rhythm with a nocturnal rise in testosterone followed by a decline during the day. Testosterone is necessary to induce and maintain secondary sexual characteristics, lean muscle mass, bone density and for normal sexual behaviour and cognitive function in men.
M, Byrne, E, Nieschlag
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Men behaving madly: testosterone replacement therapy
BMJ, 2010When young, they get overexcited, climb trees, and fight. As adolescents, their earphones blare out thrash metal, and they grunt in response to any question. Testosterone makes them spotty, hairy, and moody, and sport becomes their only social expression.
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