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Testosterone replacement therapy
British Journal of Hospital Medicine, 2007Hypgonadism has important adverse effects on the health and quality of life of affected men, but remains underdiagnosed in clinical practice. This article reviews the physiology, causes and diagnosis of hypogonadism and the potential benefits of treatment with testosterone replacement ...
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Pharmacogenetics of Testosterone Replacement Therapy
Pharmacogenomics, 2009Variable phenotypes of androgen insensitivity exist in humans, mainly owing to defective, mutated androgen receptors. A more subtle modulation of androgen effects is related to the CAG repeat polymorphism ([CAG]n) in exon 1 of the androgen receptor gene, in vitro, transcription of androgen-dependent target genes is attenuated with increasing length of ...
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Testosterone replacement therapy and cardiovascular risk
Nature Reviews Cardiology, 2019Testosterone is the main male sex hormone and is essential for the maintenance of male secondary sexual characteristics and fertility. Androgen deficiency in young men owing to organic disease of the hypothalamus, pituitary gland or testes has been treated with testosterone replacement for decades without reports of increased cardiovascular events.
Thiago Gagliano-Jucá, Shehzad Basaria
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Advances in Testosterone Replacement Therapy
2008The major goal of androgen substitution is to replace testosterone at levels as close to physiological concentrations as is possible. The mainstay of testosterone susbstitution are parenteral testosterone esters (enanthate and cypionate) to be administered every 2-3 weeks.
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Testosterone replacement therapy in male hypogonadism
Journal of Endocrinological Investigation, 2003In human males 6-7 mg of testosterone are secreted by the testes in a circadian rhythm with a nocturnal rise in testosterone followed by a decline during the day. Testosterone is necessary to induce and maintain secondary sexual characteristics, lean muscle mass, bone density and for normal sexual behaviour and cognitive function in men.
M, Byrne, E, Nieschlag
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Blood donation and testosterone replacement therapy
Transfusion, 2017BACKGROUNDPolycythemia is the most common adverse effect of testosterone replacement therapy (TRT) and may predispose patients to adverse vascular events. Current Canadian guidelines recommend regular laboratory monitoring and discontinuing TRT or reducing the dose if the hematocrit exceeds 54% (hemoglobin ≥180 g/L). This threshold has been interpreted
Benjamin, Chin-Yee +4 more
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Testosterone Replacement Therapy for Testosterone Deficiency in Older Men
Clinics in Geriatric MedicineThis review explores the increasing use of testosterone therapy in aging men, driven by the need to address age-related symptoms like decreased libido, muscle weakness, and anemia. Studies such as the Testosterone Trials and Testosterone Replacement Therapy for Assessment of Long-term Vascular Events and Efficacy Response in Hypogonadal Men trial show ...
Amber, McMahon, Richard J, Fantus
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Testosterone replacement therapy and cardiovascular events
BMJ, 2014In February 2014, The BMJ published a personal view by Sidney Wolfe of Public Citizen—a US anti-pharmaceutical pressure group trying to obtain black box warnings for testosterone products.1 The article presented summaries from two recent papers that claimed increased cardiovascular risk with testosterone replacement therapy (TRT).2 3 In July 2014, the
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Testosterone Replacement Therapy in Orthopaedic Surgery
Journal of the American Academy of Orthopaedic SurgeonsTestosterone replacement therapy (TRT) is an indicated treatment of several medical conditions including late-onset hypogonadism, congenital syndromes, and gender affirmation hormonal therapy. Increasing population age, medical benefits, and public awareness of TRT have resulted in increased prevalence of its utilization.
Randy M. Cohn +2 more
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Testosterone Replacement Therapy and Prostate Cancer
Urologic Clinics of North America, 2007The long-standing concern that testosterone replacement therapy (TRT) may increase the risk of prostate cancer (PCa) has come under new scrutiny. Arguments used to support this concern lack a scientific basis. The original assertion by Huggins that administration of testosterone (T) caused "enhanced growth" of PCa was based on only a single patient ...
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