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Cardiovascular Safety of Testosterone-Replacement Therapy
New England Journal of Medicine, 2023The cardiovascular safety of testosterone-replacement therapy in middle-aged and older men with hypogonadism has not been determined.In a multicenter, randomized, double-blind, placebo-controlled, noninferiority trial, we enrolled 5246 men 45 to 80 years of age who had preexisting or a high risk of cardiovascular disease and who reported symptoms of ...
Shalender, Bhasin +2 more
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Testosterone Replacement Therapy
Archives of Andrology, 1998The benefits conferred by testosterone replacement therapy are substantial, both in the short term for the eradication of symptoms of androgen deficiency, and in the long term for the prevention of osteoporosis. As with any long-term treatment there are risks that must be considered, but overall the benefits achieved far outweigh potential risk ...
E, Velázquez, G, Bellabarba Arata
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Testosterone Replacement Therapy in Chronic Kidney Disease Patients [PDF]
Nutrients, 2022 (Background) The aim of our study was to evaluate the efficacy and safety of testosterone replacement therapy (TRT) in men with chronic kidney disease and hypogonadism on conservative and hemodialysis treatment. (Methods) The studied population consisted
Aleksandra Rymarz +2 more
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Testosterone replacement therapy and erectile dysfunction
International Journal of Impotence Research, 2022Testosterone (T) deficiency and erectile dysfunction (ED) are independently functionally and socially impairing, and their concurrence in men can be challenging to treat. Successful management requires an understanding of the mechanisms through which T underlies normal erectile function. While the literature elucidating some of these mechanisms is vast
Ifeanyi C. Onyeji, Raul I. Clavijo
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Testosterone Replacement Therapy for Sexual Symptoms
Sexual Medicine Reviews, 2019Several data have clearly shown that the endocrine system-and androgens in particular-play a pivotal role in regulating all the steps involved in the male sexual response cycle. Accordingly, testosterone (T) replacement therapy (TRT) represents a cornerstone of pharmacologic management of hypogonadal subjects with erectile dysfunction.The aim of this ...
Rastrelli G +6 more
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Testosterone replacement therapy and cardiovascular disease
International Journal of Impotence Research, 2022The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy.
Jeremy M. Auerbach, Mohit Khera
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Testosterone replacement therapy
Medicine, 2009Abstract Testosterone replacement therapy is a well-tolerated and established treatment for hypogonadism, providing excellent clinical and biochemical relief from the effects of sex steroid deficiency. This review gives a practical clinical guide to managing testosterone replacement therapy.
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