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Testosterone Replacement Therapy for Sexual Symptoms
Sexual Medicine Reviews, 2019Several data have clearly shown that the endocrine system-and androgens in particular-play a pivotal role in regulating all the steps involved in the male sexual response cycle. Accordingly, testosterone (T) replacement therapy (TRT) represents a cornerstone of pharmacologic management of hypogonadal subjects with erectile dysfunction.The aim of this ...
Rastrelli G +6 more
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Testosterone replacement therapy
British Journal of Hospital Medicine, 2007Hypgonadism has important adverse effects on the health and quality of life of affected men, but remains underdiagnosed in clinical practice. This article reviews the physiology, causes and diagnosis of hypogonadism and the potential benefits of treatment with testosterone replacement ...
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Pharmacogenetics of Testosterone Replacement Therapy
Pharmacogenomics, 2009Variable phenotypes of androgen insensitivity exist in humans, mainly owing to defective, mutated androgen receptors. A more subtle modulation of androgen effects is related to the CAG repeat polymorphism ([CAG]n) in exon 1 of the androgen receptor gene, in vitro, transcription of androgen-dependent target genes is attenuated with increasing length of ...
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Testosterone replacement therapy
Medicine, 2009Abstract Testosterone replacement therapy is a well-tolerated and established treatment for hypogonadism, providing excellent clinical and biochemical relief from the effects of sex steroid deficiency. This review gives a practical clinical guide to managing testosterone replacement therapy.
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Testosterone replacement therapy and cardiovascular disease
International Journal of Impotence Research, 2022The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy.
Jeremy M. Auerbach, Mohit Khera
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Testosterone replacement therapy and cardiovascular risk
Nature Reviews Cardiology, 2019Testosterone is the main male sex hormone and is essential for the maintenance of male secondary sexual characteristics and fertility. Androgen deficiency in young men owing to organic disease of the hypothalamus, pituitary gland or testes has been treated with testosterone replacement for decades without reports of increased cardiovascular events.
Thiago Gagliano-Jucá, Shehzad Basaria
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Advances in Testosterone Replacement Therapy
2008The major goal of androgen substitution is to replace testosterone at levels as close to physiological concentrations as is possible. The mainstay of testosterone susbstitution are parenteral testosterone esters (enanthate and cypionate) to be administered every 2-3 weeks.
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Testosterone Replacement Therapy and Prostate Health
Current Urology Reports, 2012There is an emerging evolution in the understanding of the relationship between the prostate and testosterone. It has long been generally believed that with testosterone replacement therapy (TRT), increasing serum testosterone levels led to prostatic growth and worsening of voiding dysfunction and associated complications.
A Scott, Polackwich +2 more
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Testosterone replacement therapy in male hypogonadism
Journal of Endocrinological Investigation, 2003In human males 6-7 mg of testosterone are secreted by the testes in a circadian rhythm with a nocturnal rise in testosterone followed by a decline during the day. Testosterone is necessary to induce and maintain secondary sexual characteristics, lean muscle mass, bone density and for normal sexual behaviour and cognitive function in men.
M, Byrne, E, Nieschlag
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Testosterone Replacement Therapy for Testosterone Deficiency in Older Men
Clinics in Geriatric MedicineThis review explores the increasing use of testosterone therapy in aging men, driven by the need to address age-related symptoms like decreased libido, muscle weakness, and anemia. Studies such as the Testosterone Trials and Testosterone Replacement Therapy for Assessment of Long-term Vascular Events and Efficacy Response in Hypogonadal Men trial show ...
Amber, McMahon, Richard J, Fantus
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