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Contemporary treatment options for male hypogonadism
Journal of Education, Health and Sport, 2023
Introduction
Male hypogonadism is a disease in which testicular function is impaired. Its symptoms are due to testosterone deficiency and most of them show low specificity.Paweł Sojka, Joanna Popiołek, Jakub Szczerba, Szymon Pokora, Agata Stefanowicz, Dominika Pokładnik, Katarzyna Jeleń, Karolina Pokora, Adam Podsiedlik, Alicja Poloczek +9 moredoaj +1 more sourceGenetic Determinants of Serum Testosterone Concentrations in Men [PDF]
, 2011 Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity.Frank H de Jong, Lyytikäinen LP, Vasan, Ramachandran S, Uitterlinden AG, Wichmann HE, Zhuang WV, Wu, TS, Liu, YM, Rivadeneira Ramirez, F. (Fernando), Lorentzon, M, Murray, A, Harris, Tamara B, Murray Anna, Tajar, A., Kähönen M, Lehtimäki Terho, Stolk, Lisette, Völzke Henry, Mellström, D, Wichmann, H.-E., Reincke, M, Kiel, D.P. (Douglas), Stolk Lisette, Robin Haring, Uitterlinden, Andre G., Bidlingmaier, M, David Karasik, Miljkovic, I, Ziv, E. (Elad), Penninx B, Coviello, A.D., Murabito Joanne M., Pye, SR, EMAS Study Group (), Ljunggren, Osten, Liu, Y, Murabito JM, Uitterlinden, André G, Perry, J.R., Karlsson, Magnus, Wallaschofski, H, Brenda Penninx, Murray, Anna, Ziv E, Lyytikäinen, Leo Pekka, Wallaschofski, H., Marcello Maggio, Perry, John R. B., Lunetta, Kathryn L., Vandenput Liesbeth, Frank H. de Jong, Wichmann, H.E. (Heinz Erich), Wu, Tsung-Sheng, John-Olov Jansson, Uitterlinden, AG, Haring, R., Hofman, A., Tamara B Harris, Koster A, Koster, A, Harris, T.B. (Tamara), Rivadeneira F, Karlsson, Magnus,, Voelker, Uwe, Lunetta, KL, Harris, Tamara, Tamara B. Harris, Murray, A. (Anna), Lehtimäki, Terho (Tay), Heier, Margit, Eriksson, A., Melzer, D, Wu Tsung-Sheng, Miljkovic I, Ohlsson Claes, Rivadeneira, F, Bhasin, S, Murabito, J. (Joanne), Murray A, Petersen, A.K., Nauck, M., Pye, Stephen R., Vandenput, Liesbeth, Petersen AK, Ferrucci, L. (Luigi), Lunetta Kathryn L., Eriksson, A, Huhtaniemi Ilpo T., Eriksson, J, Lehtimaki, T., Penninx, B.W.J.H., Eriksson A, Ulloor Jagadish, Annemarie Koster, Kiel Douglas P., Hofman Albert, Abdelouahid Tajar, Reincke Martin, Eriksson J, Coviello, A.D, Nauck, Matthias, Koster, Annemarie, Kähönen Mika, Völker, U. (Uwe), Kiel, Douglas P., Tajar, A. (Abdelouahid), Ulloor, J, Kähönen, M, Wu, T.-S., Liu Y, Ohlsson, C, Melzer, David, Völzke, H. (Henry), Miljkovic, Iva, Mellström D, Nauck M, Perry JR, Frederick C. W. Wu, Iva Miljkovic, Reincke, M., De Jong, Frank H., Ulloor, J. (Jagadish), Wichmann, H. E., Dan Mellström, Nilsson Maria, Penninx Brenda, Fernando Rivadeneira, Lyytikäinen, L-P, Frederick C W Wu, Eriksson, Anna-Lena,, Miljkovic, I. (Iva), Eriksson Anna, John R B Perry, Hammond, G.L., Jansson JO, Holliday, Kate L., Jansson, JO, Martin Reincke, Ohlsson, C. (Claes), Hammond GL, Pye, Stephen R, MAGGIO, Marcello Giuseppe, Ferrucci, L, Mellstrom, Dan, Murabito, Joanne M., Stolk, L., Nilsson, Maria, Maggio, Marcello, Ramachandran S Vasan, Harris TB, Wu Frederick C. W., Wu, Frederick C. W., Uitterlinden, A.G. (André), Heier, M, Lund University., Kate L. Holliday, Luigi Ferrucci, Douglas P Kiel, de Jong, Frank H, Coviello, AD, Nilsson, M. (Maria), Völzke, H, Haring R., Mika Kähönen, Uitterlinden, A. G., Hofman A, Tajar, Abdelouahid, Wallaschofski, Henri, Raitakari, O, Wu, F.C., Ferrucci Luigi, Vandenput L, Ljunggren, Östen,, Haring, R. (Robin), Emas, SG, EMAS Study Group, Wu, FCW, Teumer, A., Joel Eriksson, Haring Robin, Zhuang, Wei Vivian, Hammond, Geoffrey L., Kiel, Douglas P, Volker, U., Nilsson, Maria,, Stephen R. Pye, Teumer, A, Perry, J.R.B. (John), Vasan, Ramachandran S., Matthias Nauck, Lyytikäinen, Leo-Pekka (Tay), Joanne M Murabito, Koster, A., Wu, F.C.W., Tajar, A, Jansson, John Olov, Petersen, Ann Kristin, Heier M, Heier, M. (Margit), Meitinger T, Mattias Lorentzon, Harris, TB, Tsung-Sheng Wu, Lorentzon, Mattias,, Kiel, D.P., Coviello AD, Bhasin, S., Lunetta, K.L. (Kathryn), Raitakari, Olli, Mellström, Dan,, Bidlingmaier, M. (Martin), Murabito, J.M., Claes Ohlsson, Perry, J.R.B., Wu, T.S., Vandenput, L, Petersen, AK, Huhtaniemi, I.T. (Ilpo), Nilsson M, Pye, S.R., Petersen Ann-Kristin, Hofman, Albert, Jansson, John-Olov,, Yongmei Liu, Teumer Alexander, André G. Uitterlinden, Vandenput, L. (Liesbeth), Meitinger, Thomas, Douglas P. Kiel, Jong, Frank, Volzke, H., Karlsson, M.K. (Magnus), Kathryn L. Lunetta, Voelzke, Henry, Völker Uwe, Wei Vivian Zhuang, Wu FC, Lyytikäinen, L.-P. (Leo-Pekka), Vasan, R.S., Ann-Kristin Petersen, Lehtimäki, T. (Terho), Thomas Meitinger, Kate L Holliday, Karasik, D, Lyytikainen, Leo-Pekka, Holliday KL, Miljkovic Iva, Eriksson, Joel, Lorentzon Mattias, Wallaschofski Henri, Ilpo T. Huhtaniemi, Koster Annemarie, Lorentzon, M., Bidlingmaier, Martin, Stolk, L. (Lisette), Huhtaniemi, Ilpo T, Coviello Andrea D., Osten Ljunggren, Lunetta KL, Huhtaniemi IT, Bidlingmaier, M., Ferrucci, L., Wu, Tsung Sheng, Maggio, M, David Melzer, Vandenput, L., Tajar A, Henry Völzke, Wu TS, Stolk L, Lehtimaki, Terho, Ilpo T Huhtaniemi, Lehtimäki, T, Lorentzon M, H Erich Wichmann, Mellstrom, D., null null, Ziv, E., Vandenput, Liesbeth,, Heier, M., Tajar Abdelouahid, Eriksson, Joel,, Reincke, Martin, Wichmann, H Erich, Penninx, B, Holliday, K.L., Karasik D, Stephen R Pye, Holliday, KL, Teumer, A. (Alexander), Hofman, Bert, Andrea D. Coviello, Völker U, Liu, Y. (YongMei), Lyytikäinen, L.-P., Karlsson, M.K., Mellström Dan, Wallaschofski, H. (Henri), Ferrucci, Luigi, Meitinger, T., Nilsson, M., Penninx, BW, Coviello, Andrea D, Jorma Viikari, Ljunggren Östen, Hammond Geoffrey L., Heier Margit, Ziv Elad, Rivadeneira Fernando, Haring, R, Lunetta, Kathryn L, Ohlsson, C., Meitinger Thomas, Uitterlinden, André, Viikari J, Holliday Kate L., Lorentzon, Mattias, Lorentzon, M. (Mattias), Wu, T-S, Margit Heier, Miljkovic, I., Bhasin S, Petersen, A-K, O'Neill, Terence, Eriksson, J., Rivadeneira, Fernando, Lyytikäinen, LP, Völker, Uwe, Hammond, Geoffrey L, Bidlingmaier Martin, de Jong Frank H., Haring, Robin, Karlsson MK, Murray, A., Raitakari, O., Harris, T.B., Penninx, Brenda, Kähönen, M. (Mika), Nilsson, M, Karasik, D. (David), Olli Raitakari, Kahonen, M., Ohlsson, Claes,, Völzke, Henry, Liu, Y.M., Perry, JR, Wichmann, HE, H. Erich Wichmann, Coviello, Andrea D., Völker, U, Lunetta, K.L., Viikari, J., Jansson, J-O, Viikari, J. (Jorma), Lyytikäinen Leo-Pekka, Vasan Ramachandran S., Perry, John R.B., Kiel, DP, Martin Bidlingmaier, Ziv, Elad, Murabito, JM, Petersen, A.-K., Raitakari Olli, Teumer, Alexander, Harris, Tamara B., Leo-Pekka Lyytikäinen, Elad Ziv, Pye SR, Lyytikainen, L.P., Ramachandran S. Vasan, Emas Study Group,, Nauck Matthias, Nauck, M, Vasan, RS, Karlsson, Magnus K, Henri Wallaschofski, Melzer D, Uitterlinden, André; id_orcid, Kahonen, Mika, Rivadeneira, F., Liu, Yongmei, Holliday, K.L. (Kate), Holliday, Kate L, Viikari, J, Völzke H, Ulloor, J., Raitakari O, Jagadish Ulloor, Maggio, M., Perry, JRB, Jansson, J.O., Joanne M. Murabito, Pye Stephen R., Hofman, A. (Albert), Lehtimäki T, Bhasin, Shalender, Melzer David, Viikari Jorma, de Jong, F.H., Coviello, A.D. (Andrea), Albert Hofman, Perry John R. B., Geoffrey L Hammond, Ulloor J, Huhtaniemi, Ilpo T., Harris Tamara B., Meitinger, T, Uitterlinden André G., André G Uitterlinden, Maggio, M. (Marcello), Melzer, D. (David), Melzer, D., Maria Nilsson, Reincke, M. (Martin), Ljunggren, Ö., Zhuang, WV, Karasik, D., Viikari, Jorma, Karlsson, MK, Zhuang, W.V., Huhtaniemi, IT, Wu, Frederick CW, Liesbeth Vandenput, Anna Eriksson, Huhtaniemi, I.T., Ziv, E, Uitterlinden, A.G., Karasik, David, Liu Yongmei, Teumer A, Eriksson Joel, Wichmann, Heinz-Erich, Alexander Teumer, Geoffrey L. Hammond, Nauck, M. (Matthias), Magnus K Karlsson, Kiel DP, Vasan, R.S. (Ramachandran Srini), Ohlsson C, Anna Murray, Karlsson, Magnus K., Ulloor, Jagadish, Ferrucci L, Hammond, G.L. (Geoffrey), John R. B. Perry, Koster, A. (Annemarie), Ljunggren, O, Karlsson Magnus K., Ljunggren O, Vasan RS, Shalender Bhasin, Kähönen, Mika (Tay), Bhasin Shalender, Jong, F.H. (Frank) de, de Jong FH, Wichmann, H. Erich, Penninx, B., Wallaschofski H, Raitakari, O. (Olli), Hofman, A, Reincke M, Perry, John R B, Perry, John RB, Pye, S.R. (Stephen), Penninx, B.W.J.H. (Brenda), Wu, Frederick C W, Stolk, L, Andrea D Coviello, Magnus K. Karlsson, Bidlingmaier M, Jansson, John-Olov, Wu, FC, Petersen, Ann-Kristin, Zhuang Wei Vivian, Hammond, GL, Bhasin, S. (Shalender), Eriksson, J. (Joel), Meitinger, T. (Thomas), Mellström, D. (Dan), Uwe Völker, Liu, Y., Murabito, Joanne M, Kathryn L Lunetta, de Jong, FH, Wichmann H. Erich, Eriksson, Anna, Ohlsson, Claes, Lisette Stolk, Terho Lehtimäki, Jansson John-Olov, Maggio Marcello, Karasik David +491 morecore +4 more sourcesNormalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 Background Atrial fibrillation (AF) is the most common cardiac dysrhythmia associated with significant morbidity and mortality. Several small studies have reported that low serum total testosterone (TT) levels were associated with a higher incidence of ...Rishi Sharma, Olurinde A. Oni, Kamal Gupta, Mukut Sharma, Ram Sharma, Vikas Singh, Deepak Parashara, Surineni Kamalakar, Buddhadeb Dawn, Guoqing Chen, John A. Ambrose, Rajat S. Barua +11 moredoaj +1 more sourceTranscriptional Profiling of Luteinizing Hormone Receptor-Deficient Mice Before and after Testosterone Treatment Provides Insight into the Hormonal Control of Postnatal Testicular Development and Leydig Cell Differentiation [PDF]
, 2010 Luteinizing hormone (LH) is a key regulator of male fertility through its effects on testosterone secretion by Leydig cells. Transcriptional control of this is, however, currently poorly understood.Affara, Nabeel, Abel, M, Ellis, Peter J.I., Dunmore, B., Bauer, Johann W., Griffin, Darren K. +5 morecore +1 more sourceThe effects of being in a "new relationship" on levels of testosterone in men [PDF]
, 2015 In light of previous research showing that different types of relationships affect levels of testosterone in men, this study examined whether categorizing relationship types according to relationship length can shed further light on variations in levels ...Rebecca Owens, Elliott, Hannah R, Walden, Hannah R, Walden, Hannah, Owens, R., Wetherell, Mark, Owens, Rebecca, Elliott, Hannah, Wetherall, MA, Farrelly, Daniel, Mark A. Wetherell, Walden, H.R., Daniel Farrelly, Hannah R. Elliott, Wetherell, M.A., Hannah R. Walden, Elliott, H.R. +16 morecore +1 more sourceSingle‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer
Advanced Science, EarlyView.Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei +19 morewiley +1 more sourceSynthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides
Angewandte Chemie International Edition, EarlyView.Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup +9 morewiley +1 more source
