Results 81 to 90 of about 24,793 (277)

Aspects of testosterone replacement therapy in men with type 2 diabetes mellitus and testosterone deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2019
Background. Testosterone deficiency is a medical condition that adversely affects male sexuality, reproduction, general health and quality of life. Testosterone therapy can improve the symptoms of testosterone deficiency and possibly stop the development
V.Ye. Luchytskyy, M.D. Tronko, Ye.V. Luchytskyy   +2 more
doaj   +1 more source

Interaction between Testosterone and Apolipoprotein E ε4 Status on Cognition in Healthy Older Men [PDF]

, 2005
Reduced testosterone levels have been implicated as a potential causative factor in cognitive decline with older age. Men who possess the apolipoprotein E (APOE) 4 allele have an increased risk of developing Alzheimer’s disease; however, no studies have
Chubb, S.A.P., Foster, J.K., Drummond, P.D., Burkhardt, M.S., Yeap, B.B., Clarnette, R.M., Bruce, D.G.   +6 more
core   +1 more source

Healthcare Costs Following Medical Gender‐Affirmation: Evidence From Whole‐of‐Population Australian Administrative Data

Health Economics, EarlyView.
ABSTRACT Gender incongruence in trans and nonbinary (“trans”) populations is often associated with psychological distress and increased demand for mental healthcare. Gender‐affirming hormone therapy (GAHT) is a key component of care for many trans people, yet long‐term evidence around its cost implications remains limited despite increasing uptake and ...
Karinna Saxby, Dennis Petrie, Brendan J. Nolan   +2 more
wiley   +1 more source

Testosterone deficiency in the adult males [PDF]

, 2012
Testosterone deficiency leads to multiple problems but can be difficult to diagnose.
Cachia, Mario J.
core  

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Testosterone Replacement Therapy

, 2018
Male hypogonadism (HG) can be defined according to its etiology as primary (pHG) when caused by any diseases affecting the testes, or as secondary (sHG) when due to a pituitary or hypothalamic dysfunction. Both fertility and testosterone (T) can be theoretically restored in sHG by removing the precipitating cause and/or by appropriate endocrine therapy.
S. Ferri, O. Prontera, Alessandra Sforza, Giuseppe Corona, Giulia Rastrelli, Mario Maggi, Yacov Reisman   +6 more
openaire   +2 more sources

The History of Estrogen Therapy [PDF]

, 2019
Research on hormone therapies has been evolving rapidly with controversy close behind. The first goal of this project was to investigate a controversy regarding testosterone replacement therapy treatment when associated with lower urinary tract symptoms.
Kohn, Grace, Kohn, Grace.
core   +2 more sources

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Pharmacology of testosterone replacement therapy preparations [PDF]

Translational Andrology and Urology, 2016
The goal of testosterone replacement therapy (TRT) is to return serum testosterone levels to within physiologic range and improve symptoms in hypogonadal men. Some of the symptoms aimed to improve upon include decreased libido, erectile dysfunction, infertility, hot flashes, depressed mood, and loss of muscle mass or hair.
Shoskes, Jennifer J., Wilson, Meghan K., Spinner, Michael L.   +2 more
openaire   +2 more sources