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A systems biology approach for the characterization of tetanospasmin production for vaccine production in tetanus vaccines

open access: yes, 2015
Licona-Cassani, Cuauhtemoc   +6 more
openaire   +2 more sources

Tetanus

open access: yes
Tetanus is a fatal disease caused by tetanospasmin exotoxins produced by C. tetani, an anaerobic gram-positive bacterium. Although the disease can be prevented by vaccination, it is still a serious toxic fatal infection.
, JOSÉ Marcelino Aragão Fernandes
exaly   +1 more source

Tetanospasmin

2000
Abstract The clinical syndrome of tetanus occurs as a result of the action of the protein neurotoxin tetanospasmin on the CNS. The toxin is a 150-kDa protein produced within contaminated wounds by Clostridium tetani (3). The spores of this organism are widespread, particularly in the soil, where they are protected from direct sunlight.
openaire   +1 more source

[Recent advances in the molecular mechanism of action of bacterial toxins, in particular of diphtheria, cholera, coli, botulinum and shigella toxins as well as tetanospasmin and the toxins of staphylococcus aureus].

Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984
Great progress was achieved in the clarification of the molecular structure and the mechanism of action of the toxins of pathogenic forms of bacteria. Proportions of toxins of Corynebacterium diphtheriae and of Pseudomonas aeruginosa transfer from the NAD and ADP-ribose protein to an amino acid of the elongation factor 2.
openaire   +1 more source

STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : VII. THE DIFFERENTIATION OF TETANOLYSIN AND TETANOSPASMIN.

The Journal of experimental medicine, 2010
Tetanolysin and tetanospasmin possess in common the immunological properties of the group of "antitoxinogens." Both of them are contained in undeteriorated culture fluids of the tetanus bacillus, but each of them represents a distinct and separate antigenic substance. Experimental data illustrating points of difference in their properties are presented
openaire   +1 more source

Polyclonal Antibody Production and Purification against Tetanospasmin

2014
Nazarian, Shahram   +6 more
openaire   +1 more source

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