Results 1 to 10 of about 209,078 (338)

Assessing the impact of the 2018 tetanus guidelines on knowledge and practices of emergency physicians in trauma patients: a national survey study [PDF]

PeerJ, 2023
Background Tetanus remains a significant public health issue in China, with the approach of anti-tetanus prophylaxis in the emergency department resulting in both overuse, particularly of human tetanus immune globulin (TIG), and underuse with the tetanus
Junling Gao, Xiaxia Yu, Guanghui Cao, Xiaoming He, Pingde Zhang, Joseph Walline, Yuanxi Wang, Xingjuan Yu, Jun Xu, Thuan-Quoc Thach, Yong Liu   +10 more
doaj   +2 more sources

Clinical Profile, Management and Outcome in Paediatric Patients with Tetanus: A Case Series [PDF]

Journal of Clinical and Diagnostic Research, 2023
Tetanus is an acute infectious disease, caused by spores of the bacterium Clostridium tetani. The spores are found everywhere in the environment, particularly in soil, ash, intestinal tracts/faeces of animals and humans, on the surfaces of skin and rusty
Arpita Manish Patel, Dhruti Manish Pandya, Kamleshkumar G Rathod, Ketan D Gadhavi, Bharat Muliya   +4 more
doaj   +1 more source

The threat of a new tetanus outbreak due to urban flooding disaster requires vigilance: a narrative review

Acute Medicine & Surgery, 2023
Vaccines for tetanus prevention have rapidly progressed, and the number of outbreaks, especially the incidence of tetanus in developed countries, has decreased dramatically. However, the mortality rate associated with severe tetanus remains high. Tetanus
Junko Yamaguchi, Kosaku Kinoshita
doaj   +1 more source

Infant rhesus macaques as a non-human primate model of Bordetella pertussis infection

BMC Infectious Diseases, 2021
Background The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly
Wenwen Jiang, Chen Wei, Dachao Mou, Weilun Zuo, Jiangli Liang, Xiao Ma, Lichan Wang, Na Gao, Qin Gu, Peng Luo, Yan Ma, Jingyan Li, Shuyuan Liu, Li Shi, Mingbo Sun   +14 more
doaj   +1 more source

Faktor-Faktor Yang Berhubungan Dengan Ibu Hamil Dalam Melakukan Imunisasi Tetanus Toxoid

Citra Delima, 2022
Imunisasi Tetanus Toxoid (TT) adalah toksin kuman tetanus yang telah dimurnikan yang di berikan pada bayi, anak dan ibu sebagai usaha memberikan perlindungan terhadap penyakit tetanus Imunisasi Tetanus Toxoid ini juga diberikan pada ibu hamil dan wanita ...
desti widya astuti
doaj   +1 more source

Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double‐Blind, Dose Escalation, Placebo‐ and Positive‐Controlled, Phase 1/2 Trial

Advanced Science, 2021
Tetanus is a fatal but vaccine‐preventable disease. The currently available tetanus vaccines are tetanus toxoid (TT)‐based. Although these vaccines are generally effective, challenges in vaccine development and access remain.
Xiaowei Xu, Rui Yu, Lanlan Xiao, Jie Wang, Meihong Yu, Junjie Xu, Yajun Tan, Xiao Ma, Xiaoxin Wu, Jiangshan Lian, Kaizhou Huang, Xiaoxi Ouyang, Sheng Bi, Shipo Wu, Xiaoyan Wang, Jiandi Jin, Ling Yu, Huafen Zhang, Qi Wei, Jinfa Shi, Wei Chen, Lanjuan Li   +21 more
doaj   +1 more source

Functional characterization of the catalytic site of the tetanus toxin light chain using permeabilized adrenal chromaffin cells [PDF]

, 1993
The molecular events underlying the inhibition of exocytosis by tetanus toxin were investigated in permeabilized adrenal chromaffin cells. We found that replacement of amino acid residues within the putative zinc binding domain of the tetanus toxin light
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Alder, Alder, Anderegg, Archer, Barbara Höhne-Zell, Baumert, Bennett, Binz, Bittner, Bittner, Bittner, Bommert, Brigitte Stecher, Brose, Coleman, Cushman, Dayanithi, Dayanithi, Eisel, Eisel, Elferink, Fö, Facchiano, Facchiano, Greenberg, Hö, Hata, Jahn, Jongeneel, Knaus, Kurazono, Link, Lorand, Manfred Gratzl, Matteoli, Mochida, Mochida, Niemann, Sö, Sü, Sanders, Schiavo, Schiavo, Schiavo, Stecher, Stecher, Stecher, Stecher, Thomas, Thomas, Ushkaryov, Vallee, Weller, Weller, Wright   +57 more
core   +1 more source

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Ahnert-Hilger, G., Dayanithi, G., Gratzl, Manfred, Lnk, H., Nordmann, J. J., Weller, U.   +5 more
core   +1 more source

Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]

, 1994
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Binz, T., Dayanithi, G., Gratzl, Manfred, Höhne-Zell, B., Niemann, H., Stecher, B., Weller, U., Yamasaki, S.   +7 more
core   +1 more source

Synaptobrevin cleavage by the tetanus toxin light chain is linked to the inhibition of exocytosis in chromaffin cells [PDF]

, 1994
Exocytosis of secretory granules by adrenal chromaffin cells is blocked by the tetanus toxin light chain in a zinc specific manner. Here we show that cellular synaptobrevin is almost completely degraded by the tetanus toxin light chain within 15 min.
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Anderegg, Axel Ecker, Barbara Höhne-Zell, Baumert, Baumert, Bhakdi, Bittner, Bittner, Bittner, Blasi, Blasi, Brose, Dayanithi, Dayanithi, de, Facchiano, Facchiano, Gratzl, Gratzl, Hö, Hö, Kurazono, Laemmli, Link, Manfred Gratzl, Matteoli, Mochida, Mochida, Penner, Sö, Sö, Schiavo, Schiavo, Schiavo, Schiavo, Stecher, Stecher, Stecher, Stecher, Towbin, Ulrich Weller, Weller, Weller, Wessel   +46 more
core   +1 more source