Results 21 to 30 of about 30,062 (202)

Antitoxin in the Treatment of Tetanus [PDF]

The American Journal of the Medical Sciences, 1894
n ...
  +5 more sources

Can the Problem of Uncontrolled and Unnecessary Tetanus Vaccination of Workers Working in Industrial Workplaces Be Solved?

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021
Introduction: Since antibodies against tetanus decrease over time and disappear completely, especially in older ages, it is recommended to give tetanus booster every 10 years for adults. However, in some risky occupational groups, tetanus vaccination can
Selma TOSUN, Halil ERKAN, Hülya ÖZKAN ÖZDEMİR, Alpay ARI, Mustafa APAK   +4 more
doaj   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations [PDF]

Clin Pharmacol Ther
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Liu X, Liu Z, Kuang X, Wang Y, Liu X, Ding J, Zhou X, Zhou X, Liang Q, Zhang M, Zhao H, Tan Q, Zheng W, Liao H, Lemech C, Wang W.   +15 more
europepmc   +2 more sources

Assessing the impact of the 2018 tetanus guidelines on knowledge and practices of emergency physicians in trauma patients: a national survey study [PDF]

PeerJ, 2023
Background Tetanus remains a significant public health issue in China, with the approach of anti-tetanus prophylaxis in the emergency department resulting in both overuse, particularly of human tetanus immune globulin (TIG), and underuse with the tetanus
Junling Gao, Xiaxia Yu, Guanghui Cao, Xiaoming He, Pingde Zhang, Joseph Walline, Yuanxi Wang, Xingjuan Yu, Jun Xu, Thuan-Quoc Thach, Yong Liu   +10 more
doaj   +2 more sources

Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial [PDF]

, 2022
Background Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus ...
Tuyen, Pham Thi, Day, Nicholas Pj, Turner, Hugo C, Nguyen, Nguyen Thanh, Tan Thanh, Tran, Yen, Lam Minh, Hong, Duc Du, Thuy, Duong Bich, Thuy, Tran Thi Diem, Phong, Nguyen Thanh, Duong, Ha Thi Hai, Wyncoll, Duncan, Nhat, Phung Tran Huy, Thwaites, C Louise, Van Tan, Le, Thwaites, Guy E, Lieu, Pham Thi, Khanh, Phan Nguyen Quoc, Geskus, Ronald B, Hanh, Bui Thi Bich, Tho, Phan Vinh, Loan, Huynh Thi, Van Vinh Chau, Nguyen, Kestelyn, Evelyne, Phu, Nguyen Hoan, van Doorn, H Rogier, Oanh, Pham Kieu Nguyet, Van Hao, Nguyen, Dung, Nguyen Thi Phuong, Nghia, Ho Dang Trung   +29 more
core   +1 more source

Case report: A case of tetanus in a dog: cranial nerve involvement and imaging findings

Frontiers in Veterinary Science, 2023
An 11 years old male Labrador cross presented with unilateral vestibular signs, ipsilateral facial paresis, moderate obtundation, ptyalism, and paraparesis.
Kylie Grant, Sam Long
doaj   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann   +7 more
core   +1 more source

An Unusual Case of Chronic Relapsing Tetanus Associated with Mandibular Osteomyelitis [PDF]

, 2009
A 55-year-old man underwent radiation therapy due to malignant lymphoma of the neck. Eight years after the therapy he developed tetanus. It appears that the radiation therapy resulted in mandibular necrosis, and that this lesion may have been the ...
Tomiyama, Masahiko, Suzuki, Chieko, Jackson, Mandy, Yamamoto-Watanabe, Yukiko, Watanabe, Mitsunori, Kawarabayashi, Takeshi, Fujimuro, Masahiro, Shoji, Mikio, Shirahama, Ikumi, Wakasaya, Yasuhito, Nakahata, Naoko, Kimura, Tamaki, Matsubara, Etsuro, Takamura, Ayumi, Seino, Yusuke   +14 more
core   +1 more source

The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]

, 1992
The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Lnk, H., Gratzl, Manfred   +5 more
core   +1 more source

TETANUS TREATED WITH ANTITOXIN. [PDF]

JAMA: The Journal of the American Medical Association, 1899
At this time, when the serum therapy of disease is receiving close attention, it seems well to report all cases in which a test of this mode of treatment has been made. Tetanus is not the least important of the diseases in which antitoxic serum is employed as a curative means.
openaire   +1 more source