Results 51 to 60 of about 69,229 (203)

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie International Edition, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Perception and utilization of tetanus toxoid immunization among pregnant women attending a tertiary centre in North-West Nigeria

Journal of Drug Delivery and Therapeutics, 2018
Background: Despite the availability of inexpensive and effective tetanus-toxoid-containing vaccines, elimination of maternal and neonatal tetanus worldwide has become a herculean task, particularly in low-income countries, due to poor immunization ...
K. Awosan, Mairo Hassan
semanticscholar   +1 more source

Effect of HIV exposure and timing of antiretroviral therapy initiation on immune memory responses to diphtheria, tetanus, whole cell pertussis and hepatitis B vaccines

Expert Review of Vaccines, 2019
Objectives: We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to ...
Omphile E. Simani, Alane Izu, Marta C. Nunes, Avy Violari, Mark F. Cotton, Nadia Van Niekerk, Peter V. Adrian, Shabir A. Madhi   +7 more
doaj   +1 more source

Patient‐Derived IgG Epitope Mapping of Bet v 1 Reveals Hypoallergenic Peptide Candidates for Safe and Next‐Generation Allergen Immunotherapy

Clinical &Experimental Allergy, EarlyView.
Mapping IgG epitopes of the major birch allergen Bet v 1 identified patient‐derived, hypoallergenic peptides that did not trigger degranulation. These findings support a novel, safer approach for peptide‐based allergen immunotherapy that leverages naturally induced IgG specificities from allergic individuals. ABSTRACT Background Allergen immunotherapy (
Lara Šošić, Marta Paolucci, Alessandro Streuli, David A. Melillo, Tianchi Jiang, Raffaela Campana, Claudia C. V. Lang, Thomas M. Kündig, Christian Steuer, Klaus Eyer, Pål Johansen   +10 more
wiley   +1 more source

Neonatal tetanus in St. Mary’s Hospital Lacor: A case report

Clinical Case Reports, 2020
Umbilical stump sepsis in a nonpassively immunized neonate poses a high risk to neonatal tetanus. Management of neonatal tetanus is still a great challenge in resource‐limited settings where some health facilities lack tetanus toxoid containing vaccines,
Ronald Okidi, Vanusa Da Consolação Sambo, Jacob Eyul   +2 more
doaj   +1 more source

Knowledge and health beliefs of reproductive-age women in Alexandria about tetanus toxoid immunization

Journal of the Egyptian Public Health Association, 2020
Background Maternal neonatal tetanus is a substantial public health problem in many developing countries. In 2017, nearly, 30,848 newborns died of neonatal tetanus; thus, high immunization coverage remains a necessity. This study aims to assess knowledge
Azza Mehanna, Mervat H. Ali, Ibrahim Kharboush   +2 more
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Co‐Coverage of Essential Interventions Across the Health System Continuum of Care for Improving Child Nutrition in Ethiopia

Maternal &Child Nutrition, EarlyView.
ABSTRACT This study aimed to assess the coverage of essential nutrition interventions delivered through the health system and explored the relationship between co‐coverage and child‐ and maternal‐level factors, household‐level factors, and access to healthcare facilities.
Alemnesh Petros, Meron Girma, Tsedey Moges, Alemayehu Hussen, Tadesse Kebebe, Meseret Woldeyohannes, Teshome Asefa, Daniel Abera, Yirgalem Tadesse, Getachew Tollera, Mesay Hailu, Arnaud Laillou, Stanley Chitekwe, Kaleab Baye, Ramadhani Noor, Masresha Tessema   +15 more
wiley   +1 more source

Tetanus toxoid and CCL3 improve DC vaccines in mice and glioblastoma patients

Nature, 2015
After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients as immunotherapy.
D. Mitchell, Kristen A. Batich, M. Gunn, Min-Nung Huang, L. Sanchez-Perez, S. Nair, Kendra L Congdon, E. Reap, G. Archer, A. Desjardins, A. Friedman, H. Friedman, J. Herndon, A. Coan, R. McLendon, D. Reardon, J. Vredenburgh, D. Bigner, J. Sampson   +18 more
semanticscholar   +1 more source

The absence of iron deficiency effect on the humoral immune response of piglets to tetanus toxoid

Veterinární Medicína, 2007
The aim of this study was to investigate an antibody response to tetanus toxoid in iron-deficient piglets. Ten piglets were not given any iron preparation until the age of 21 days.
M. Svoboda, K. Nechvatalova, J. Krejci, J. Drabek, R. Ficek, M. Faldyna   +5 more
doaj   +1 more source