Results 151 to 160 of about 15,241 (253)

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney   +12 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki   +4 more
wiley   +1 more source

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

open access: yesAngewandte Chemie, Volume 138, Issue 17, 20 April 2026.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire   +3 more
wiley   +2 more sources

Quantifying Under‐Ice Phytoplankton Blooms in the Changing Arctic and Southern Oceans

open access: yesGeophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract Historically, polar marine phytoplankton were thought to primarily grow after the seasonal breakup of sea ice, when there is plentiful light available in the surface ocean. However, observations of substantial productivity under sea ice has called this assumption into question.
Courtney M. Payne   +4 more
wiley   +1 more source

Observed Drivers of Rapid Sea‐Ice Melt Events in the Arctic During Summer

open access: yesGeophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract Rapid, episodic sea‐ice loss during the summer is commonly attributed to strong winds from Arctic storms, but the physical relationship between winds and ice melt remains poorly understood. Therefore, we use observations of the air‐sea‐ice interface from autonomous buoys deployed throughout the Arctic over the last two decades to examine the ...
P. M. Finocchio   +3 more
wiley   +1 more source

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