Dermal Concentration Versus Systemic Bioavailability of Topical Lidocaine and Tetracaine: An Exploratory Pharmacokinetic Pilot Study in Göttingen Minipigs [PDF]
PharmaceuticsBackground: Lidocaine, classified as an amide-type agent, and tetracaine, designated as an ester-type agent, are frequently co-formulated for dermatologic procedures.
Paweł Biernat +5 more
doaj +2 more sources
How effective is tetracaine 4% gel, before a venipuncture, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [PDF]
BMC Pediatrics, 2007 Background Procedural pain relief is sub-optimal in neonates. Topical tetracaine provides pain relief in children. Evidence of its efficacy and safety in neonates is limited.
Sherlock Rebecca +5 more
doaj +4 more sources
How effective is tetracaine 4% gel, before a peripherally inserted central catheter, in reducing procedural pain in infants: a randomized double-blind placebo controlled trial [ISRCTN75884221] [PDF]
BMC Medicine, 2006 Background Procedural pain relief is sub-optimal in infants, especially small and vulnerable ones. Tetracaine gel 4% (Ametop®, Smith-Nephew) provides pain relief in children and larger infants, but its efficacy in smaller infants and for peripherally ...
Blanchard Colline +5 more
doaj +3 more sources
Research on the use of tetracaine hydrochloride jelly surface anesthesia in combination with intravenous anesthesia for pain-free cystoscopy [PDF]
Frontiers in MedicineObjectiveThis study aimed to evaluate the efficacy and safety of tetracaine hydrochloride jelly surface anesthesia in combination with intravenous anesthesia for painless cystoscopy.MethodsThis study was conducted at the Department of Urology, Beijing ...
Wenjie Bai +4 more
doaj +2 more sources
Metabolomics Changes of Serum and Tissues in Mice Died of Acute Tetracaine Poisoning [PDF]
Fayixue Zazhi, 2021 Objective To study the changes of metabolites in serum and tissues （kidney, liver and heart） of mice died of acute tetracaine poisoning by metabolomics, to search for potential biomarkers and related metabolic pathways, and to provide new ideas for the ...
LIU Wen-qiao, BAI Rui, MA Chun-ling, et al.
doaj +1 more source
BJUI Compass, 2021 Objective To assess the effectiveness and safety of dorsal penile nerve block (DPNB) compared with tetracaine gel in analgesia for men undergoing rigid cystoscopy.
Yan Qiu +3 more
doaj +1 more source
Intrinsic aerobic capacity sets a divide for aging and longevity [PDF]
, 2011 <p><b>Rationale:</b> Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease.
Charles F. Burant +17 more
core +13 more sources
Efficacy and safety of a lidocaine/tetracaine medicated patch or peel for dermatologic procedures: a meta-analysis [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundTo justify the use of the lidocaine/tetracaine medicated patch or peel as a preventive treatment for reducing pain and discomfort in adults and children. We reviewed randomized controlled trials (RCTs) to evaluate the efficacy and safety of the
Won Oak Kim +2 more
doaj +1 more source
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]
, 2020 Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M +6 more
core +2 more sources