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Medical Clinics of North America, 1982
Tetracyclines continue to be used extensively on a world-wide basis because of their unusually broad antimicrobial spectrum and their relative safety. The first generation tetracyclines are used almost exclusively via the oral route; the second generation tetracyclines may be used orally or intravenously. Intramuscular administration is not recommended.
B A, Cunha, J B, Comer, M, Jonas
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Tetracyclines continue to be used extensively on a world-wide basis because of their unusually broad antimicrobial spectrum and their relative safety. The first generation tetracyclines are used almost exclusively via the oral route; the second generation tetracyclines may be used orally or intravenously. Intramuscular administration is not recommended.
B A, Cunha, J B, Comer, M, Jonas
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Synthesis of (−)-Tetracycline [PDF]
Journal of the American Chemical Society, 2005 We describe a convergent, enantioselective synthesis of (-)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB precursor 2 in 10 steps (11% yield), as previously described, and the latter compound was activated toward Diels-Alder cycloaddition by the introduction of an alpha-phenylthio group (two steps ...
Dionicio Siegel +2 more
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Clinics in Dermatology, 2003
T etracylines were introduced in clinical medicine back in 1948 with their first representative, chlortetracycline. They show a broad spectrum of activity, can be used via many routes of administration, and are relatively safe. During the last 55 years, many facts have come to light revealing the positive and negative effects of tetracyclines, both ...
Jana Kazandjieva +2 more
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T etracylines were introduced in clinical medicine back in 1948 with their first representative, chlortetracycline. They show a broad spectrum of activity, can be used via many routes of administration, and are relatively safe. During the last 55 years, many facts have come to light revealing the positive and negative effects of tetracyclines, both ...
Jana Kazandjieva +2 more
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Cellular and Molecular Life Sciences, 2009
Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Gerard D. Wright +2 more
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Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome.
Gerard D. Wright +2 more
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Obstetrics and Gynecology Clinics of North America, 1992
The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
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The tetracyclines are inexpensive drugs that are of primary value in treating nonpregnant women who have acute urethral syndrome or endocervicitis due to Chlamydia trachomatis. They are contraindicated in pregnancy because they are injurious to fetal teeth and bone.
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Gel chromatography of tetracycline and derivatives of tetracycline
Journal of Chromatography A, 1968Abstract The elution characteristics of tetracycline (TC), anhydrotetracycline (ATC) and 4- epi -anhydrotetracycline (EATC) were studied on Sephadex gel under various conditions of pH and salt concentration. The adsorption of the compounds was strong in acid solvents but diminished as the pH was elevated.
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