Results 101 to 110 of about 162,449 (380)

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. [PDF]

, 2017
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia.1 Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in
Barbareschi, Cassel, Colina, Firinu, Firinu, Laasonen, Nast, Nguyen, Wendling, Zaba   +9 more
core   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Laccase from Melanocarpus albomyces: Molecular Docking Analysis with First-Generation Tetracyclines Through a Mechanistic Approach

Compounds
Laccases are versatile enzymes capable of oxidizing a wide variety of antibiotics. In this study, the mechanism of catalytic oxidation of first-generation tetracyclines, namely, oxytetracycline, tetracycline, and chlortetracycline, by the Melanocarpus ...
José Muñoz-Espinoza, Germán Barriga-González, Gino Corsini, Sebastián Lagos, Andrés Barriga González, Nadia Gavilán de Fátima   +5 more
doaj   +1 more source

Consumption of antibiotics within ambulatory care in Malta [PDF]

, 2011
Background: Antibiotic use is recognised as the most important driver for the development of antimicrobial resistance in community pathogens. Surveillance is therefore critical for improvement programmes.
Borg, Michael Angelo, Zarb, Peter
core  

An expanded multilocus sequence typing scheme for propionibacterium acnes : investigation of 'pathogenic', 'commensal' and antibiotic resistant strains [PDF]

, 2012
The Gram-positive bacterium Propionibacterium acnes is a member of the normal human skin microbiota and is associated with various infections and clinical conditions.
Barnard, E. (Emma), Cove, Jonathan, Eady, Anne, Gao, Anna, Li, Huiying, McDowell, A. (Andrew), Nagy, I. (István), Nord, Carl Erik, Patrick, Sheila, Tomida, Shuta   +9 more
core   +3 more sources

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Antimicrobial Resistance: We Must Pursue a Collaborative, Global Approach and Use a "One Health" Approach. [PDF]

, 2019
Treating infection is a key part of the work of most clinicians [...]
Lipman, J, Lonsdale, DO
core   +1 more source

Tetracyclines Revisited: Tetracyclines in the Field of Dermatology

Dermatology
Background: Tetracyclines are a class of broad-spectrum antibiotics favored by dermatologists. Over the last decade, the clinical efficacy of tetracyclines has expanded into various dermatoses. Summary: This review tries to encompass the possible indications of tetracycline in the field of dermatology and possible mechanisms of action.
Kim, Yoon-Seob, Kim, Hei Sung
openaire   +2 more sources