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The history of the tetracyclines

Annals of the New York Academy of Sciences, 2011
The history of the tetracyclines involves the collective contributions of thousands of dedicated researchers, scientists, clinicians, and business executives over the course of more than 60 years. Discovered as natural products from actinomycetes soil bacteria, the tetracyclines were first reported in the scientific literature in 1948.
M. Nelson, S. Levy
semanticscholar   +4 more sources

An achieved strategy for magnetic biochar for removal of tetracyclines and fluoroquinolones: Adsorption and mechanistic studies.

Bioresource Technology, 2022
In this study, poplar wood biochar modified with Fe3O4 (MPBC) was prepared using poplar wood as carbon source and used to remove tetracyclines and fluoroquinolones.
Xianzhao Zhang   +5 more
semanticscholar   +1 more source

Label-free and Dye-free Fluorescent Sensing of Tetracyclines Using a Capture-Selected DNA Aptamer.

Analytical Chemistry, 2022
Tetracyclines are a group of important antibiotics with a common four-ring scaffold. While most tetracyclines are currently used only in animals, their leaching into the environment and residues in food have caused health concerns.
Yichen Zhao   +4 more
semanticscholar   +1 more source

The Tetracyclines

Medical Clinics of North America, 1982
Tetracyclines continue to be used extensively on a world-wide basis because of their unusually broad antimicrobial spectrum and their relative safety. The first generation tetracyclines are used almost exclusively via the oral route; the second generation tetracyclines may be used orally or intravenously. Intramuscular administration is not recommended.
B A, Cunha, J B, Comer, M, Jonas
openaire   +2 more sources

Innovative Dual-Emitting Ratiometric Fluorescence Sensor for Tetracyclines Detection Based on Boron Nitride Quantum Dots and Europium Ions

, 2020
On account of the excessive residues and serious detriments, it is imminent to develop an efficient method to determine tetracyclines (TCs) for protecting human health.
Kairong Yang   +6 more
semanticscholar   +1 more source

Bi2O3-Sensitized TiO2 Hollow Photocatalyst Drives the Efficient Removal of Tetracyclines under Visible Light.

Inorganic Chemistry, 2020
The complete removal of tetracycline residuals under visible light still is a challenging task because of their robust ring structure. To tackle this issue, we explore a novel Bi2O3-sensitized TiO2 visible-light photocatalyst by combining p-n ...
Qingye Shi   +6 more
semanticscholar   +1 more source

Transcriptional activation by tetracyclines in mammalian cells.

Science, 1995
A transcriptional transactivator was developed that fuses the VP16 activation domain with a mutant Tet repressor from Escherichia coli. This transactivator requires certain tetracycline (Tc) derivatives for specific DNA binding.
M. Gossen   +5 more
semanticscholar   +1 more source

Amino-Functionalized Al-MOF for Fluorescent Detection of Tetracyclines in Milk.

Journal of Agricultural and Food Chemistry, 2019
A fluorescent method for detection of tetracyclines (TCs) in milk was developed by using the NH2-MIL-53(Al) nanosensor synthesized via a one-pot hydrothermal method. The nanosensor had a crystalline nanoplates structure with rich groups of -NH2 and -COOH.
Chunhua Li   +9 more
semanticscholar   +1 more source

Synthesis of (−)-Tetracycline [PDF]

open access: possibleJournal of the American Chemical Society, 2005
We describe a convergent, enantioselective synthesis of (-)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB precursor 2 in 10 steps (11% yield), as previously described, and the latter compound was activated toward Diels-Alder cycloaddition by the introduction of an alpha-phenylthio group (two steps ...
Dionicio Siegel   +2 more
openaire   +2 more sources

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