Results 241 to 250 of about 23,011 (262)
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The auto‐oxidation of tetrahydrobiopterin
European Journal of Biochemistry, 1988The product of the aerobic oxidation of tetrahydrobiopterin, quinonoid dihydrobiopterin, is unstable and rapidly rearranges to form a 7,8‐dihydropteridine. Kaufman [Kaufman, S. (1967) J. Biol. Chem. 242, 3934–3943] identified the stable product produced in 0.1 M phosphate pH 6.8, as 7,8‐dihydrobiopterin. However, Armarego et al. [Armarego, W. L.
M D, Davis, S, Kaufman, S, Milstien
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International database of tetrahydrobiopterin deficiencies
Journal of Inherited Metabolic Disease, 1995SummaryApproximately 2% of newborns with hyperphenylalaninaemia are deficient in tetrahydrobiopterin. Selective screening must be performed in all instances where hyperphenylalaninaemia is detected by neonatal screening. In the last 20 years, 308 patients with tetrahydrobiopterin deficiencies have been recognized as a result of screening carried out ...
N, Blau, I, Barnes, J L, Dhondt
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Maternal Phenylketonuria and Tetrahydrobiopterin
Pediatrics, 2008Untreated maternal phenylketonuria (PKU) results in a significant occurrence of microcephaly and congenital heart disease in the offspring. Before the documentation of this fact by Lenke and Levy1 in 1980, there was confusion as to the occurrence of these abnormalities.
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Tetrahydrobiopterin Metabolism
1988Tetrahydrobiopterin is the cofactor for the hydroxylation of phenylalanine, tyrosine and tryptophan and is therefore essential for the production of monoamine neurotransmitters. Neopterin, a biosynthetic precusor of tetrahydrobiopterin, and biopterin appear in urine. In normal subjects the urinary neopterin to biopterin ratio has been found to be about
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Tetrahydrobiopterin-(BH4-)Mangelkrankheiten
2014Die Krankheitsgruppe umfasst 6 angeborene Stoffwechselstorungen, die mit einem Tetrahydrobiopterinmangel (BH4-Mangel) entweder aufgrund einer gestorten BH4-Biosynthese oder eines gestorten BH4-Recyclings einhergehen. Tetrahydrobiopterin (BH4) ist ein essenzieller Kofaktor bei der Biosynthese der Neurotransmitter Dopamin und Serotonin und bei der ...
T. Opladen, N. Blau
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Tetrahydrobiopterin and phenylketonuria
The Journal of Pediatrics, 2011PORTA, FRANCESCO +4 more
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