Results 151 to 160 of about 13,831 (202)

Model-guided chemical environment and metabolic network design to couple pathways with cell fitness. [PDF]

open access: yesMetab Eng Commun
Kakko von Koch N   +7 more
europepmc   +1 more source

In Vitro Antimalarial Activity of Tetrahydrofolate Dehydrogenase Inhibitors

open access: closedThe American Journal of Tropical Medicine and Hygiene, 1984
Three tetrahydrofolate dehydrogenase (dihydrofolate reductase = EC 1.5.1.3) inhibitors were tested for antimalarial activity against Plasmodium falciparum, using an in vitro radioisotopic technique. Activity of each drug was tested in both normal RPMI medium 1640 and in modified medium (containing no p-aminobenzoic acid and 2.27 X 10(-8) M folic acid ...
David Sixsmith   +3 more
openalex   +3 more sources

Purification of tetrahydrofolate dehydrogenase by affinity chromatography

open access: closedBiochimica et Biophysica Acta (BBA) - Enzymology, 1972
Abstract Tetrahydrofolate dehydrogenase (5,6,7,8-tetrahydrofolate:NADP + oxidoreductase, EC 1.5.1.3; formerly known as dihydrofolate reductase) from a subline of the L1210 lymphoma has been purified to apparent homogeneity with high recovery by simple steps using agarose to which the enzyme inhibitor amethopterin was coupled. A crude (NH 4 ) 2 SO 4
Jack Gauldie, Brian L. Hillcoat
openalex   +3 more sources

Tetrahydrofolate dehydrogenase cytochemistry in acute lymphoblastic leukemia

open access: closedEuropean Journal of Haematology, 1988
We studied the cytochemical distribution of tetrahydrofolate dehydrogenase (FH4D), an enzyme involved in nucleic acid metabolism and thus in cell proliferation and differentiation processes, in bone marrow blasts from 37 cases of acute lymphoblastic leukemia (ALL), of whom 23 were pediatric patients. 26 cases were analyzed at onset, 11 in relapse.
Rosangela Invernizzi   +6 more
openalex   +3 more sources

A critical examination of some histochemical methods for demonstrating tetrahydrofolate dehydrogenase

open access: closedThe Histochemical Journal, 1972
Two different methods, one proposed by us (1969, 1970) and the other by Onicescuet al. (1970), for the histochemical demonstration of tetrahydrofolate dehydrogenase have been compared using as test materials frozen sections of mouse liver and blood smears of laboratory animals that had been infected experimentally with malaria.
Giuseppe Gerzeli, Paola De Piceis Polver
openalex   +3 more sources

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