Results 101 to 110 of about 50,736 (296)

Structure and folding of the Tetrahymena telomerase RNA pseudoknot

Nucleic Acids Research, 2016
Telomerase maintains telomere length at the ends of linear chromosomes using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT).
D. Cash, J. Feigon
semanticscholar   +1 more source

Unraveling the Carcinogenic Mechanisms of Food Contaminants: An Integrated in Silico Framework Combining Network Toxicology, Machine Learning, and Molecular Docking

Journal of Food Science, Volume 90, Issue 11, November 2025.
ABSTRACT Food contamination poses a significant global health threat with carcinogenic potential, though the molecular pathways connecting contaminants to cancer remain poorly understood. This study sought to identify key molecular targets mediating the carcinogenic effects of nine prevalent dietary contaminants: glyphosate, perfluorooctane sulfonate ...
Bangsheng Chen, Maomao Li, Yi Gu, Wenzhu Lou, Shuaishuai Huang, Feiyan Mao, Lian Tan, Zhiyan Wang   +7 more
wiley   +1 more source

Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila

Science China Life Sciences, 2016
Genomic distribution of the nucleosome, the basic unit of chromatin, contains important epigenetic information. To map nucleosome distribution in structurally and functionally differentiated micronucleus (MIC) and macronucleus (MAC) of the ciliate ...
Xiao Chen, Shan Gao, Yifan Liu, Yuanyuan Wang, Yurui Wang, Weibo Song   +5 more
semanticscholar   +1 more source

PHOSPHATASE ACTIVITY IN TETRAHYMENA

The Biological Bulletin, 1951
1. Tetrahymzena gcleii E possesses phosphatases (nucleotidases) capable of hydrolyzing nucleic acid and its components at a very rapid rate. Eighty per cent of the phosphate in 0.0005 M adenylic acid is released in 22 hours when the population level is 20,000 cells/ml.2.
A M, ELLIOTT, R L, HUNTER
openaire   +4 more sources

UPLC‐ESI‐QTOF‐MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation

Chemistry &Biodiversity, Volume 22, Issue 10, October 2025.
ABSTRACT Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions.
Ines El Mannoubi, Nuha M. Alghamdi, Seham H. Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N. Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira   +8 more
wiley   +1 more source

Toxic and genotoxic potential evaluation of soil samples by bioassays

Acta Agriculturae Slovenica, 2005
Soil samples were obtained from Slovenian industrial region Šaleška dolina and aqueous leachates were prepared. The toxicity and genotoxicity potential of these aqueous fractions have been evaluated by in vitro toxicity and genotoxicity bioassays ...
Barbara LAH, Miha AVBERŠEK, Gregor GORJANC, Romana MARINŠEK LOGAR   +3 more
doaj   +1 more source

The Tetrahymena metallothionein gene family: twenty-one new cDNAs, molecular characterization, phylogenetic study and comparative analysis of the gene expression under different abiotic stressors

BMC Genomics, 2016
Ciliate metallothioneins (MTs) are included in family 7 of the MT superfamily. This family has been divided into two main subfamilies: 7a or CdMTs and 7b or CuMTs. All ciliate MTs reported have been isolated from different Tetrahymena species and present
Patricia de Francisco, Laura María Melgar, S. Díaz, A. Martín-González, J. Gutiérrez   +4 more
semanticscholar   +1 more source

Probing the Inhibitory Potential of Halogenated Symmetrical Formamidine Against MAO‐A and MAO‐B: Structural Elucidation, Molecular Dynamic Simulation and DFT Computational Studies

Chemistry &Biodiversity, Volume 22, Issue 10, October 2025.
ABSTRACT A halogenated symmetrical formamidine, N,N′‐bis(3‐chloro‐4‐fluorophenyl)formamidine (FCF) was synthesized by the condensation reaction between triethyl orthoformate and 3‐chloro‐4‐fluoroaniline in 1:2 ratio. The compound FCF was characterized by FT‐IR, mass, NMR (1H and 13C) spectroscopic techniques and the purity was confirmed by elemental ...
Segun D. Oladipo, Robert C. Luckay, Samuel O. Olalekan, Abosede A. Badeji, Tunde L. Yusuf, Adesola A. Adeleke, Nonkosi Matinise   +6 more
wiley   +1 more source

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution

Nature, 2021
Z. Su, Kaiming Zhang, K. Kappel, Shanshan Li, Michael Z. Palo, G. Pintilie, R. Rangan, B. Luo, Yuquan Wei, R. Das, W. Chiu   +10 more
semanticscholar   +1 more source

Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes*

Journal of Biological Chemistry, 2016
In most eukaryotes, telomere maintenance relies on telomeric repeat synthesis by a reverse transcriptase named telomerase. To synthesize telomeric repeats, the catalytic subunit telomerase reverse transcriptase (TERT) uses the RNA subunit (TER) as a ...
Heather E. Upton, H. Chan, J. Feigon, K. Collins   +3 more
semanticscholar   +1 more source